N-tert.-butyloxycarbonyl tyrosyl, D-methionyl, glycyl, phenylanalyl, 1-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl> proline

Base Information

Chemical Name:N-tert.-butyloxycarbonyl tyrosyl, D-methionyl, glycyl, phenylanalyl, 1-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl> proline
CAS No.:115615-66-2
Molecular Formula:C₄₉H₆₆N₆O₁₇S
Molecular Weight:1043.16
Hs Code.:

N-tert.-butyloxycarbonyl tyrosyl, D-methionyl, glycyl, phenylanalyl, <N<sup>1</sup>-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl> proline

Synonyms:

Suppliers and Price of N-tert.-butyloxycarbonyl tyrosyl, D-methionyl, glycyl, phenylanalyl, 1-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl> proline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-tert.-butyloxycarbonyl tyrosyl, D-methionyl, glycyl, phenylanalyl, 1-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl> proline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-tert.-butyloxycarbonyl tyrosyl, D-methionyl, glycyl, phenylanalyl, 1-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl> proline

There total 9 articles about N-tert.-butyloxycarbonyl tyrosyl, D-methionyl, glycyl, phenylanalyl, 1-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl> proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 41355-50-4,51642-81-0,58484-22-3,70128-27-7,70145-20-9,94482-21-0,98300-76-6
2,3,4,6-tetra-O-acetyl-D-glucosyl-1-amine

: 66863-93-2
N-(t-butoxycarbonyl)-L-tyrosyl-D-methionyl-glycyl-L-phenylalanyl-L-proline

: 115615-66-2,115730-55-7,137568-46-8
N-tert.-butyloxycarbonyl tyrosyl, D-methionyl, glycyl, phenylanalyl, 1-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl> proline

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; -15 deg C, 1 h then R_.T_., overnight;
DOI:10.1016/S0040-4020(01)89802-1

Reference yield: 5.0%

: Acetic acid (2R,3R,4S,5R,6R)-3,5-diacetoxy-2-acetoxymethyl-6-[((S)-pyrrolidine-2-carbonyl)-amino]-tetrahydro-pyran-4-yl ester

: 115615-64-0
Boc-Tyr-DMet-Gly-Phe-OH

: 115615-66-2,115730-55-7,137568-46-8
N-tert.-butyloxycarbonyl tyrosyl, D-methionyl, glycyl, phenylanalyl, 1-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl> proline

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; -15 deg C, 1 h then R_.T_., overnight;
DOI:10.1016/S0040-4020(01)89802-1

Reference yield:

: 41355-50-4,51642-81-0,58484-22-3,70128-27-7,70145-20-9,94482-21-0,98300-76-6
2,3,4,6-tetra-O-acetyl-D-glucosyl-1-amine

: 115615-66-2,115730-55-7,137568-46-8
N-tert.-butyloxycarbonyl tyrosyl, D-methionyl, glycyl, phenylanalyl, 1-2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl> proline

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / N-methylmorpholine, isobuthylchlorocarbonate / dimethylformamide / -15 deg C, 1 h then R_.T_., 2 h

2: hydrogen / 10percent palladium on charcoal / methanol

3: 5 percent / 1-hydroxybenzotriazole, N,N -dicyclohexylcarbodiimide / tetrahydrofuran / -15 deg C, 1 h then R_.T_., overnight

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)89802-1