1-[3-(4-Amino-phenyl)-1-isopropoxy-propyl]-5-fluoro-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[3-(4-Amino-phenyl)-1-isopropoxy-propyl]-5-fluoro-1H-pyrimidine-2,4-dione
CAS No.:99676-75-2
Molecular Formula:C₁₆H₂₀FN₃O₃
Molecular Weight:321.352
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[3-(4-Amino-phenyl)-1-isopropoxy-propyl]-5-fluoro-1H-pyrimidine-2,4-dione

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Technology Process of 1-[3-(4-Amino-phenyl)-1-isopropoxy-propyl]-5-fluoro-1H-pyrimidine-2,4-dione

There total 11 articles about 1-[3-(4-Amino-phenyl)-1-isopropoxy-propyl]-5-fluoro-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99676-71-8
2-{4-[3-(5-Fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-isopropoxy-propyl]-phenyl}-isoindole-1,3-dione

: 99676-75-2
1-[3-(4-Amino-phenyl)-1-isopropoxy-propyl]-5-fluoro-1H-pyrimidine-2,4-dione

Guidance literature:: With hydrazine hydrate; In methanol; for 2h; Yield given; Heating;

Reference yield:

: 122-97-4
3-Phenyl-1-propanol

: 99676-75-2
1-[3-(4-Amino-phenyl)-1-isopropoxy-propyl]-5-fluoro-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 11 steps

1: Et₃N / CH₂Cl₂ / 0.25 h

2: 50 percent / HNO₃ / 5 h / Ambient temperature

3: 99 percent / NaOMe / methanol

4: 93 percent / Fe, AcOH / acetone; H₂O / 1.5 h / Heating

5: 76 percent / acetic acid / 1 h / Heating

6: 98 percent / 30percent H₂O₂ / acetic acid / 0.25 h / 80 - 85 °C

7: 90 percent / NaOAc / 3 h / Heating

8: 2.) SnCl₄ / 2.) CH₂Cl₂

9: 84 percent / SO₂Cl₂ / CH₂Cl₂ / 2 h

10: 70 percent / dimethylformamide / 0.5 h / 100 °C

11: N₂H₄*H₂O / methanol / 2 h / Heating

With sulfuryl dichloride; dihydrogen peroxide; nitric acid; sodium methylate; sodium acetate; tin(IV) chloride; iron; hydrazine hydrate; acetic acid; triethylamine; In methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetone;

Reference yield:

: 69804-99-5
3-phenylpropanol methanesulfonate

: 99676-75-2
1-[3-(4-Amino-phenyl)-1-isopropoxy-propyl]-5-fluoro-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 10 steps

1: 50 percent / HNO₃ / 5 h / Ambient temperature

2: 99 percent / NaOMe / methanol

3: 93 percent / Fe, AcOH / acetone; H₂O / 1.5 h / Heating

4: 76 percent / acetic acid / 1 h / Heating

5: 98 percent / 30percent H₂O₂ / acetic acid / 0.25 h / 80 - 85 °C

6: 90 percent / NaOAc / 3 h / Heating

7: 2.) SnCl₄ / 2.) CH₂Cl₂

8: 84 percent / SO₂Cl₂ / CH₂Cl₂ / 2 h

9: 70 percent / dimethylformamide / 0.5 h / 100 °C

10: N₂H₄*H₂O / methanol / 2 h / Heating

With sulfuryl dichloride; dihydrogen peroxide; nitric acid; sodium methylate; sodium acetate; tin(IV) chloride; iron; hydrazine hydrate; acetic acid; In methanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; acetone;