(4R,5R)-5-{(1S,3R,4R)-3-hydroxy-1-methoxy-4-[(4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]pentyl}-4-[(2-methoxyethoxy)methoxy]-3,3-dimethyldihydrofuran-2(3H)-one

Base Information

Chemical Name:(4R,5R)-5-{(1S,3R,4R)-3-hydroxy-1-methoxy-4-[(4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]pentyl}-4-[(2-methoxyethoxy)methoxy]-3,3-dimethyldihydrofuran-2(3H)-one
CAS No.:745818-85-3
Molecular Formula:C₂₈H₄₄O₁₀
Molecular Weight:540.651
Hs Code.:

(4R,5R)-5-{(1S,3R,4R)-3-hydroxy-1-methoxy-4-[(4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]pentyl}-4-[(2-methoxyethoxy)methoxy]-3,3-dimethyldihydrofuran-2(3H)-one

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Chemical Property of (4R,5R)-5-{(1S,3R,4R)-3-hydroxy-1-methoxy-4-[(4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]pentyl}-4-[(2-methoxyethoxy)methoxy]-3,3-dimethyldihydrofuran-2(3H)-one

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Technology Process of (4R,5R)-5-{(1S,3R,4R)-3-hydroxy-1-methoxy-4-[(4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]pentyl}-4-[(2-methoxyethoxy)methoxy]-3,3-dimethyldihydrofuran-2(3H)-one

There total 12 articles about (4R,5R)-5-{(1S,3R,4R)-3-hydroxy-1-methoxy-4-[(4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]pentyl}-4-[(2-methoxyethoxy)methoxy]-3,3-dimethyldihydrofuran-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 745818-84-2
(4R,5R)-5-{(1S,3R,4R,5S,6R)-3,5-dihydroxy-1-methoxy-7-[(4-methoxybenzyl)oxy]-4,6-dimethylheptyl}-4-[(2-methoxyethoxy)methoxy]-3,3-dimethyldihydrofuran-2(3H)-one

: 745818-85-3
(4R,5R)-5-{(1S,3R,4R)-3-hydroxy-1-methoxy-4-[(4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]pentyl}-4-[(2-methoxyethoxy)methoxy]-3,3-dimethyldihydrofuran-2(3H)-one

Guidance literature:: With 4 A molecular sieve; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1055/s-2004-822389

Reference yield:

: 745818-77-3
(5R)-5-[(1S)-3-(benzyloxy)-1-methoxypropyl]-3,3-dimethylfuran-2,4(3H,5H)-dione

: 745818-85-3
(4R,5R)-5-{(1S,3R,4R)-3-hydroxy-1-methoxy-4-[(4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]pentyl}-4-[(2-methoxyethoxy)methoxy]-3,3-dimethyldihydrofuran-2(3H)-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: 64 percent / L-Selectride / tetrahydrofuran / 0.25 h / -78 °C

2.1: 73 percent / DIPEA / CH₂Cl₂ / 44.5 h / Heating

3.1: 98 percent / H₂ / Pd(OH)2/C / ethanol / 0.67 h / 20 °C

4.1: 78 percent / NMO; TPAP; 4 Angstroem molecular sieves / CH₂Cl₂ / 2 h / 0 - 20 °C

5.1: 32 mg / tetrahydrofuran; diethyl ether / 21 h / -78 - -18 °C

6.1: tetrahydrofuran; methanol / 1.17 h / -78 - -70 °C

6.2: 16 mg / NaBH₄ / methanol; tetrahydrofuran / 2.83 h

7.1: 4 mg / pinacol / methanol / 40 °C

8.1: DDQ; 4 Angstroem molecular sieves / CH₂Cl₂ / 1 h / 20 °C

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2,3-dimethyl-2,3-butane diol; 4 A molecular sieve; hydrogen; L-Selectride; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1055/s-2004-822389

Reference yield:

: 745818-78-4
(4R,5S)-5-[(1S)-3-(benzyloxy)-1-methoxypropyl]-4-hydroxy-3,3-dimethyldihydrofuran-2(3H)-one

: 745818-85-3
(4R,5R)-5-{(1S,3R,4R)-3-hydroxy-1-methoxy-4-[(4S,5R)-2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl]pentyl}-4-[(2-methoxyethoxy)methoxy]-3,3-dimethyldihydrofuran-2(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 73 percent / DIPEA / CH₂Cl₂ / 44.5 h / Heating

2.1: 98 percent / H₂ / Pd(OH)2/C / ethanol / 0.67 h / 20 °C

3.1: 78 percent / NMO; TPAP; 4 Angstroem molecular sieves / CH₂Cl₂ / 2 h / 0 - 20 °C

4.1: 32 mg / tetrahydrofuran; diethyl ether / 21 h / -78 - -18 °C

5.1: tetrahydrofuran; methanol / 1.17 h / -78 - -70 °C

5.2: 16 mg / NaBH₄ / methanol; tetrahydrofuran / 2.83 h

6.1: 4 mg / pinacol / methanol / 40 °C

7.1: DDQ; 4 Angstroem molecular sieves / CH₂Cl₂ / 1 h / 20 °C

With N-methyl-2-indolinone; tetrapropylammonium perruthennate; 2,3-dimethyl-2,3-butane diol; 4 A molecular sieve; hydrogen; N-ethyl-N,N-diisopropylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1055/s-2004-822389