6-benzyloxycarbonylamino-2-[2-[2-(7-tert-butoxycarbonylamino-heptanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: 6-benzyloxycarbonylamino-2-[2-[2-(7-tert-butoxycarbonylamino-heptanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester
• CAS No.: 757967-75-2
• Molecular Formula: C₆₀H₇₀N₆O₁₀
• Molecular Weight: 1035.25
• Mol file: 757967-75-2.mol

Synonyms:

Chemical Property of 6-benzyloxycarbonylamino-2-[2-[2-(7-tert-butoxycarbonylamino-heptanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-benzyloxycarbonylamino-2-[2-[2-(7-tert-butoxycarbonylamino-heptanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester

There total 6 articles about 6-benzyloxycarbonylamino-2-[2-[2-(7-tert-butoxycarbonylamino-heptanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Lys(Z)-OH (2389-45-9) → 6-benzyloxycarbonylamino-2-[2-[2-(7-tert-butoxycarbonylamino-heptanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester (757967-75-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: WSCI*HCl; 4-dimethylaminopyridine / dimethylformamide

2.1: HCl / dioxane

3.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / -15 °C

3.2: triethylamine / tetrahydrofuran; dimethylformamide

4.1: HCl / dioxane

5.1: PyBop; N,N-diisopropylethylamine / dimethylformamide

6.1: HCl / dioxane

7.1: PyBop; N,N-diisopropylethylamine / dimethylformamide

With hydrogenchloride; dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2004.06.105

Reference yield:

9-Fluorenylmethanol (24324-17-2) → 6-benzyloxycarbonylamino-2-[2-[2-(7-tert-butoxycarbonylamino-heptanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester (757967-75-2)

Guidance literature:

Multi-step reaction with 7 steps

1.1: WSCI*HCl; 4-dimethylaminopyridine / dimethylformamide

2.1: HCl / dioxane

3.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / -15 °C

3.2: triethylamine / tetrahydrofuran; dimethylformamide

4.1: HCl / dioxane

5.1: PyBop; N,N-diisopropylethylamine / dimethylformamide

6.1: HCl / dioxane

7.1: PyBop; N,N-diisopropylethylamine / dimethylformamide

With hydrogenchloride; dmap; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2004.06.105

Reference yield:

Boc-Lys(Z)-OFm (220064-87-9) → 6-benzyloxycarbonylamino-2-[2-[2-(7-tert-butoxycarbonylamino-heptanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-3-(1H-indol-3-yl)-propionylamino]-hexanoic acid 9H-fluoren-9-ylmethyl ester (757967-75-2)

Guidance literature:

Multi-step reaction with 6 steps

1.1: HCl / dioxane

2.1: isobutyl chloroformate; triethylamine / tetrahydrofuran / -15 °C

2.2: triethylamine / tetrahydrofuran; dimethylformamide

3.1: HCl / dioxane

4.1: PyBop; N,N-diisopropylethylamine / dimethylformamide

5.1: HCl / dioxane

6.1: PyBop; N,N-diisopropylethylamine / dimethylformamide

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2004.06.105

upstream raw materials:

7-[(tert-butoxycarbonyl)amino]heptanoic acid

Boc-Lys(Z)-OH

9-Fluorenylmethanol

Boc-Lys(Z)-OFm