2-benzyloxycarbonyl-3-cyclopent-1-enylmethyl-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-succinic acid 4-benzyl ester 1-tert-butyl ester

Base Information

Chemical Name:2-benzyloxycarbonyl-3-cyclopent-1-enylmethyl-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-succinic acid 4-benzyl ester 1-tert-butyl ester
CAS No.:202188-99-6
Molecular Formula:C₃₆H₄₄N₂O₈
Molecular Weight:632.754
Hs Code.:

2-benzyloxycarbonyl-3-cyclopent-1-enylmethyl-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-succinic acid 4-benzyl ester 1-<i>tert</i>-butyl ester

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Chemical Property of 2-benzyloxycarbonyl-3-cyclopent-1-enylmethyl-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-succinic acid 4-benzyl ester 1-tert-butyl ester

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Technology Process of 2-benzyloxycarbonyl-3-cyclopent-1-enylmethyl-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-succinic acid 4-benzyl ester 1-tert-butyl ester

There total 6 articles about 2-benzyloxycarbonyl-3-cyclopent-1-enylmethyl-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-succinic acid 4-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 159135-61-2
3-bromomethyl-1,5,5-trimethylimidazolidine-2,4-dione

: 202188-94-1
2-benzyloxycarbonyl-3-cyclopent-1-enylmethyl-succinic acid 4-benzyl ester 1-tert-butyl ester

: 202188-99-6
2-benzyloxycarbonyl-3-cyclopent-1-enylmethyl-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-succinic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:: 2-benzyloxycarbonyl-3-cyclopent-1-enylmethyl-succinic acid 4-benzyl ester 1-tert-butyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 22 ℃; for 1.33333h;

3-bromomethyl-1,5,5-trimethylimidazolidine-2,4-dione; In N,N-dimethyl-formamide; at 0 ℃; for 4h;
DOI:10.1016/S0040-4020(01)00720-7

Reference yield:

: 6851-81-6
1,5,5-trimethylhydantoin

: 202188-99-6
2-benzyloxycarbonyl-3-cyclopent-1-enylmethyl-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-succinic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 88 percent / HBr/AcOH / 4.5 h / 80 °C

2.1: NaH / dimethylformamide / 1.33 h / 22 °C

2.2: dimethylformamide / 4 h / 0 °C

With hydrogen bromide; sodium hydride; acetic acid; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)00720-7

Reference yield:

: 1528-30-9
methylenecyclopentane

: 202188-99-6
2-benzyloxycarbonyl-3-cyclopent-1-enylmethyl-2-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-ylmethyl)-succinic acid 4-benzyl ester 1-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: (R)-(+)-1,1'-bi-2-naphthol; molecular sieves (H₂O content 8 percent); (i-PrO)2TiBr₂ / CH₂Cl₂; toluene / 16 h / 22 °C

2.1: 26.68 g / Et₃N / toluene / 22 h / -15 °C

3.1: NaH / dimethylformamide / 0.5 h / 22 °C

3.2: dimethylformamide / 28 h / 22 °C

4.1: NaH / dimethylformamide / 1.33 h / 22 °C

4.2: dimethylformamide / 4 h / 0 °C

With molecular sieve; diisopropoxytitanium(IV) dibromide; (R)-1,1'-Bi-2-naphthol; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(01)00720-7