Technology Process of 5-(3-(4-(difluoromethyl)-1H-1,2,3-triazole-1-yl)phenyl)-1,3,4-thiadiazol-2-amine
There total 4 articles about 5-(3-(4-(difluoromethyl)-1H-1,2,3-triazole-1-yl)phenyl)-1,3,4-thiadiazol-2-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dimethylaminosulphur trifluoride / dichloromethane / 24 h / 20 °C
2: trifluoroacetic acid / 24 h / 60 °C
With
dimethylaminosulphur trifluoride; trifluoroacetic acid;
In
dichloromethane;
DOI:10.1021/jm2003624
- Guidance literature:
-
Multi-step reaction with 4 steps
1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 20 °C / Darkness
2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C
3: dimethylaminosulphur trifluoride / dichloromethane / 24 h / 20 °C
4: trifluoroacetic acid / 24 h / 60 °C
With
copper(ll) sulfate pentahydrate; dimethylaminosulphur trifluoride; sodium L-ascorbate; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
dichloromethane; water; dimethyl sulfoxide; tert-butyl alcohol;
1: Huisgen cycloaddition;
DOI:10.1021/jm2003624
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 20 °C
2: dimethylaminosulphur trifluoride / dichloromethane / 24 h / 20 °C
3: trifluoroacetic acid / 24 h / 60 °C
With
dimethylaminosulphur trifluoride; trifluoroacetic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm2003624
