1-[(2R,3R,4R,5R)-5-[(R)-2-((3aS,4R,6S,7R,7aR)-7-Azido-2,2-dimethyl-6-phenylsulfanyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl)-1-hydroxy-ethyl]-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2R,3R,4R,5R)-5-[(R)-2-((3aS,4R,6S,7R,7aR)-7-Azido-2,2-dimethyl-6-phenylsulfanyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl)-1-hydroxy-ethyl]-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
CAS No.:719278-96-3
Molecular Formula:C₃₆H₅₇N₅O₉SSi₂
Molecular Weight:792.114
Hs Code.:

1-[(2R,3R,4R,5R)-5-[(R)-2-((3aS,4R,6S,7R,7aR)-7-Azido-2,2-dimethyl-6-phenylsulfanyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl)-1-hydroxy-ethyl]-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Synonyms:

Suppliers and Price of 1-[(2R,3R,4R,5R)-5-[(R)-2-((3aS,4R,6S,7R,7aR)-7-Azido-2,2-dimethyl-6-phenylsulfanyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl)-1-hydroxy-ethyl]-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-[(2R,3R,4R,5R)-5-[(R)-2-((3aS,4R,6S,7R,7aR)-7-Azido-2,2-dimethyl-6-phenylsulfanyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl)-1-hydroxy-ethyl]-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-[(2R,3R,4R,5R)-5-[(R)-2-((3aS,4R,6S,7R,7aR)-7-Azido-2,2-dimethyl-6-phenylsulfanyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl)-1-hydroxy-ethyl]-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

There total 18 articles about 1-[(2R,3R,4R,5R)-5-[(R)-2-((3aS,4R,6S,7R,7aR)-7-Azido-2,2-dimethyl-6-phenylsulfanyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl)-1-hydroxy-ethyl]-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 719278-95-2
1-[10-azido-2,3-di-O-(tert-butyldimethylsilyl)-6,10,11-trideoxy-8,9-O-isopropylidene-11-phenylsulfinyl-L-galacto-D-allo-undecofuranosyl-(1,4)]uracil

: 719278-93-0
1-[10-azido-2,3-di-O-(tert-butyldimethylsilyl)-6,10,11-trideoxy-8,9-O-isopropylidene-11-S-phenyl-11-thio-L-lyxo-D-allo-undeculofuranosyl-(1,4)]uracil

: 719278-96-3
1-[(2R,3R,4R,5R)-5-[(R)-2-((3aS,4R,6S,7R,7aR)-7-Azido-2,2-dimethyl-6-phenylsulfanyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl)-1-hydroxy-ethyl]-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -20 ℃; for 0.0833333h; Title compound not separated from byproducts;
DOI:10.1081/NCN-120027831

Reference yield:

: (3aR,4S,6R,7R,7aR)-7-Azido-2,2-dimethyl-4-phenylsulfanylmethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-6-ol

: 719278-96-3
1-[(2R,3R,4R,5R)-5-[(R)-2-((3aS,4R,6S,7R,7aR)-7-Azido-2,2-dimethyl-6-phenylsulfanyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl)-1-hydroxy-ethyl]-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 12 steps

1.1: 1.83 g / sodium borohydride / methanol / 0.5 h / -20 °C

2.1: imidazole / dimethylformamide / 1 h / 0 °C

3.1: pyridine / 12 h / 20 °C

4.1: 534 mg / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 0 °C

5.1: pyridine / CH₂Cl₂ / 0.08 h / -20 °C

6.1: 614 mg / Et₃N / CH₂Cl₂ / 1 h / 20 °C

7.1: 90 percent / NaOMe / methanol / 1 h / 20 °C

8.1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

9.1: samarium diiodide; O₂ / tetrahydrofuran / -40 °C

9.2: tetrahydrofuran / 0 °C

10.1: 55 mg / sodium borohydride; AcOH / CH₂Cl₂ / 0.5 h / -20 °C

11.1: 32 mg / mCPBA / CH₂Cl₂ / 0.5 h / 0 °C

12.1: Tf₂O; pyridine / CH₂Cl₂ / 0.08 h / -20 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; samarium diiodide; trifluoromethylsulfonic anhydride; tetrabutyl ammonium fluoride; oxygen; sodium methylate; Dess-Martin periodane; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1081/NCN-120027831

Reference yield:

: 719278-88-3
(2S,3R,4S,5R)-2-azido-3,4-(dimethylmethylenedioxy)-6-phenylthio-1,5-hexanediol

: 719278-96-3
1-[(2R,3R,4R,5R)-5-[(R)-2-((3aS,4R,6S,7R,7aR)-7-Azido-2,2-dimethyl-6-phenylsulfanyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-4-yl)-1-hydroxy-ethyl]-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 11 steps

1.1: imidazole / dimethylformamide / 1 h / 0 °C

2.1: pyridine / 12 h / 20 °C

3.1: 534 mg / tetrabutylammonium fluoride / tetrahydrofuran / 2 h / 0 °C

4.1: pyridine / CH₂Cl₂ / 0.08 h / -20 °C

5.1: 614 mg / Et₃N / CH₂Cl₂ / 1 h / 20 °C

6.1: 90 percent / NaOMe / methanol / 1 h / 20 °C

7.1: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

8.1: samarium diiodide; O₂ / tetrahydrofuran / -40 °C

8.2: tetrahydrofuran / 0 °C

9.1: 55 mg / sodium borohydride; AcOH / CH₂Cl₂ / 0.5 h / -20 °C

10.1: 32 mg / mCPBA / CH₂Cl₂ / 0.5 h / 0 °C

11.1: Tf₂O; pyridine / CH₂Cl₂ / 0.08 h / -20 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; samarium diiodide; trifluoromethylsulfonic anhydride; tetrabutyl ammonium fluoride; oxygen; sodium methylate; Dess-Martin periodane; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1081/NCN-120027831