2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[(S)-3-amino-1-(3-chloro-phenyl)propylcarbamoyl]-2-chloro-phenyl}amide

Base Information

Chemical Name:2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[(S)-3-amino-1-(3-chloro-phenyl)propylcarbamoyl]-2-chloro-phenyl}amide
CAS No.:1386980-15-9
Molecular Formula:C₂₅H₂₂Cl₂N₆O₄
Molecular Weight:541.393
Hs Code.:

2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[(S)-3-amino-1-(3-chloro-phenyl)propylcarbamoyl]-2-chloro-phenyl}amide

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Chemical Property of 2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[(S)-3-amino-1-(3-chloro-phenyl)propylcarbamoyl]-2-chloro-phenyl}amide

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Technology Process of 2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[(S)-3-amino-1-(3-chloro-phenyl)propylcarbamoyl]-2-chloro-phenyl}amide

There total 7 articles about 2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[(S)-3-amino-1-(3-chloro-phenyl)propylcarbamoyl]-2-chloro-phenyl}amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21667-62-9
3-chlorobenzoylacetonitrile

: 1386980-15-9
2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[(S)-3-amino-1-(3-chloro-phenyl)propylcarbamoyl]-2-chloro-phenyl}amide

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 60 °C / Inert atmosphere

1.2: 0 °C

2.1: tetrahydrofuran / 0.5 h

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 5 °C

4.1: hydrazine hydrate / tetrahydrofuran; methanol / 2 h / 55 °C

5.1: (R,R)-WHELK-O₁ column / carbon dioxide; methanol / Resolution of racemate

6.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.2: 18 h

7.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With lithium aluminium tetrahydride; hydrazine hydrate; triethylamine; triphenylphosphine; HATU; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; carbon dioxide; N,N-dimethyl-formamide;

Reference yield:

: 1221187-20-7
3-amino-1-(3-chloro-phenyl)-propan-1-ol

: 1386980-15-9
2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[(S)-3-amino-1-(3-chloro-phenyl)propylcarbamoyl]-2-chloro-phenyl}amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 0.5 h

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 5 °C

3.1: hydrazine hydrate / tetrahydrofuran; methanol / 2 h / 55 °C

4.1: (R,R)-WHELK-O₁ column / carbon dioxide; methanol / Resolution of racemate

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

5.2: 18 h

6.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With hydrazine hydrate; triethylamine; triphenylphosphine; HATU; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; carbon dioxide; N,N-dimethyl-formamide;

Reference yield:

: [3-amino-3-(3-chloro-phenyl)-propyl]-carbamic acid tert-butyl ester

: 1386980-15-9
2-methoxy-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[(S)-3-amino-1-(3-chloro-phenyl)propylcarbamoyl]-2-chloro-phenyl}amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: (R,R)-WHELK-O₁ column / carbon dioxide; methanol / Resolution of racemate

2.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 18 h

3.1: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With triethylamine; HATU; trifluoroacetic acid; In methanol; dichloromethane; carbon dioxide; N,N-dimethyl-formamide;