4-(acetylamino)-2,6-dimethylbenzenesulfonyl chloride

Base Information

• Chemical Name: 4-(acetylamino)-2,6-dimethylbenzenesulfonyl chloride
• CAS No.: 132414-06-3
• Molecular Formula: C10H12ClNO3S
• Molecular Weight: 261.72500
• Mol file: 132414-06-3.mol

Synonyms:4-acetamido-2,6-dimethylbenzenesulfonyl chloride;4-acetylamino-2,6-dimethyl-benzenesulfonyl chloride;(4-acetamido-2,6-dimethylphenyl)sulfonyl chloride;

Chemical Property of 4-(acetylamino)-2,6-dimethylbenzenesulfonyl chloride

Chemical Property:

• PSA: 71.62000
• LogP: 3.34310

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(acetylamino)-2,6-dimethylbenzenesulfonyl chloride

There total 3 articles about 4-(acetylamino)-2,6-dimethylbenzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ 4-acetamido-2,6-dimethylbenzenesulphonyl chloride (132414-06-3)

Guidance literature:

Reference yield: 45.0%

N-acetyl-3,5-dimethylaniline (2050-45-5) → 4-acetamido-2,6-dimethylbenzenesulphonyl chloride (132414-06-3)

Guidance literature:

With chlorosulfonic acid; at 90 ℃; for 3h;

Reference yield:

3,5-dimethylaminoaniline (108-69-0) → 4-acetamido-2,6-dimethylbenzenesulphonyl chloride (132414-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent

2: ClSO₃H / 2.5 h / 60 °C

With chlorosulfonic acid; 1: Acetylation / 2: Substitution;

DOI:10.1016/S0223-5234(99)00219-6

upstream raw materials:

N-acetyl-3,5-dimethylaniline

3,5-dimethylaminoaniline

Downstream raw materials:

3.5-dimethyl-4-sulfonic acid

N-(3,5-dimethyl-4-sulfamoylphenyl)-acetamide

(4-acetamido-2,6-dimethylphenyl)sulfinic acid

3,5-Dimethyl-4-sulfamoyl-benzenesulfonyl chloride