koumine

Base Information

Chemical Name:koumine
CAS No.:119241-69-9
Molecular Formula:C₂₀H₂₂N₂O
Molecular Weight:306.407
Hs Code.:

Synonyms:

Suppliers and Price of koumine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of koumine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of koumine

There total 48 articles about koumine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: C₂₂H₂₆N₂O₃

: 1358-76-5,83705-29-7,119241-69-9
(-)-koumine

Guidance literature:: C₂₂H₂₆N₂O₃; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.25h; Inert atmosphere;

With palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 90 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acs.orglett.6b00661

Reference yield:

: C₃₃H₃₃NO₄

: 1358-76-5,83705-29-7,119241-69-9
(-)-koumine

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium carbonate / methanol; tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

2.1: pyridine / tetrahydrofuran; toluene / 2 h / -78 - -40 °C / Inert atmosphere

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

3.2: 1.5 h / -78 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / methanol / 8 h / 20 °C / Inert atmosphere

5.1: pyridine; pyridine hydrochloride / 23 h / 100 °C / Inert atmosphere

6.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

6.2: 2 h / 0 - 20 °C / Inert atmosphere

7.1: ammonia; sodium / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere

8.1: tetrahydrofuran; water / 4.5 h / 0 - 20 °C / Inert atmosphere

9.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

10.1: pyridine / 1 h / 0 - 20 °C / Inert atmosphere

11.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C / Inert atmosphere

11.2: 3 h / 90 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; oxalyl dichloride; ammonia; pyridine hydrochloride; sodium; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; dimethyl sulfoxide; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 3.1: |Swern Oxidation / 3.2: |Swern Oxidation / 7.1: |Birch Reduction;
DOI:10.1021/acs.orglett.6b00661

Reference yield:

: C₃₁H₃₁NO₃

: 1358-76-5,83705-29-7,119241-69-9
(-)-koumine

Guidance literature:: Multi-step reaction with 10 steps

1.1: pyridine / tetrahydrofuran; toluene / 2 h / -78 - -40 °C / Inert atmosphere

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C / Inert atmosphere

2.2: 1.5 h / -78 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / methanol / 8 h / 20 °C / Inert atmosphere

4.1: pyridine; pyridine hydrochloride / 23 h / 100 °C / Inert atmosphere

5.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

5.2: 2 h / 0 - 20 °C / Inert atmosphere

6.1: ammonia; sodium / tetrahydrofuran / 0.67 h / -78 °C / Inert atmosphere

7.1: tetrahydrofuran; water / 4.5 h / 0 - 20 °C / Inert atmosphere

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

9.1: pyridine / 1 h / 0 - 20 °C / Inert atmosphere

10.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 - 20 °C / Inert atmosphere

10.2: 3 h / 90 °C / Inert atmosphere

With pyridine; lithium aluminium tetrahydride; oxalyl dichloride; ammonia; pyridine hydrochloride; sodium; sodium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; 9-bora-bicyclo[3.3.1]nonane; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 2.1: |Swern Oxidation / 2.2: |Swern Oxidation / 6.1: |Birch Reduction;
DOI:10.1021/acs.orglett.6b00661