1,2,3,4-Tetrahydro-5-iodo-isoquinoline

Base Information

• Chemical Name: 1,2,3,4-Tetrahydro-5-iodo-isoquinoline
• CAS No.: 939758-80-2
• Molecular Formula: C₉H₁₀IN
• Molecular Weight: 259.09
• Mol file: 939758-80-2.mol

Synonyms:

Chemical Property of 1,2,3,4-Tetrahydro-5-iodo-isoquinoline

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

1,2,3,4-TETRAHYDRO-5-IODO-ISOQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2,3,4-Tetrahydro-5-iodo-isoquinoline

There total 2 articles about 1,2,3,4-Tetrahydro-5-iodo-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-iodoisoquinoline (58142-99-7) → 5-iodo-1,2,3,4-tetrahydroisoquinoline (939758-80-2)

Guidance literature:

With sodium tetrahydroborate; acetic acid; at 0 - 20 ℃; for 3h;

Reference yield:

isoquinolin-5-ylamine (1125-60-6) → 5-iodo-1,2,3,4-tetrahydroisoquinoline (939758-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite; potassium iodide; hydrogenchloride / water / 1 h / 0 °C / Reflux

2: acetic acid; sodium tetrahydroborate / 3 h / 0 - 20 °C

With hydrogenchloride; sodium tetrahydroborate; acetic acid; potassium iodide; sodium nitrite; In water;

Reference yield: 68.0%

5-iodo-1,2,3,4-tetrahydroisoquinoline (939758-80-2) + 3-Carboxybenzenesulfonyl chloride (4025-64-3) → C16H14INO4S (1394241-50-9)

Guidance literature:

In N,N-dimethyl-formamide; acetone; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jm3007867

upstream raw materials:

isoquinolin-5-ylamine

5-iodoisoquinoline

Downstream raw materials:

C₁₆H₁₄INO₄S

Refernces

• 1、 -. "ARYL LINKED IMIDAZOLE AND TRIAZOLE DERIVATIVES AND METHODS OF USE THEREOF FOR IMPROVING THE PHARMACOKINETICS OF A DRUG". . . Retrieved 2015/06/03.