2-Oxazolidinone, 3-[3-(2,2-dimethyl-1,3-dioxolan-4-yl)-1-oxopropyl]-4-methyl-5-phenyl-, [4S-[3(R*),4alpha,5alpha]]-

Base Information

Chemical Name:2-Oxazolidinone, 3-[3-(2,2-dimethyl-1,3-dioxolan-4-yl)-1-oxopropyl]-4-methyl-5-phenyl-, [4S-[3(R*),4alpha,5alpha]]-
CAS No.:157555-77-6
Molecular Formula:C₁₈H₂₃NO₅
Molecular Weight:333.384
Hs Code.:
DSSTox Substance ID:DTXSID901109486

Synonyms:DTXSID901109486;157555-77-6;2-Oxazolidinone, 3-[3-(2,2-dimethyl-1,3-dioxolan-4-yl)-1-oxopropyl]-4-methyl-5-phenyl-, [4S-[3(R*),4alpha,5alpha]]-

Suppliers and Price of 2-Oxazolidinone, 3-[3-(2,2-dimethyl-1,3-dioxolan-4-yl)-1-oxopropyl]-4-methyl-5-phenyl-, [4S-[3(R*),4alpha,5alpha]]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-Oxazolidinone, 3-[3-(2,2-dimethyl-1,3-dioxolan-4-yl)-1-oxopropyl]-4-methyl-5-phenyl-, [4S-[3(R*),4alpha,5alpha]]-

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:333.15762283
Heavy Atom Count:24
Complexity:486

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1C(OC(=O)N1C(=O)CCC2COC(O2)(C)C)C3=CC=CC=C3
Isomeric SMILES:C[C@H]1[C@H](OC(=O)N1C(=O)CC[C@H]2COC(O2)(C)C)C3=CC=CC=C3

Technology Process of 2-Oxazolidinone, 3-[3-(2,2-dimethyl-1,3-dioxolan-4-yl)-1-oxopropyl]-4-methyl-5-phenyl-, [4S-[3(R*),4alpha,5alpha]]-

There total 4 articles about 2-Oxazolidinone, 3-[3-(2,2-dimethyl-1,3-dioxolan-4-yl)-1-oxopropyl]-4-methyl-5-phenyl-, [4S-[3(R*),4alpha,5alpha]]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 81703-94-8
methyl (2Z)-3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]acrylate

: 157555-77-6
(4S,5R)-3-<(S)-2,2-dimethyl-1,3-dioxolane-4-propanoyl>-4-methyl-5-phenyl-2-oxazolidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / H₂ / 10percent Pd/C / ethanol

2: 97 percent / LiOH / methanol; H₂O / 48 h / Ambient temperature

3: Et₃N / tetrahydrofuran / -78 °C

4: n-BuLi / tetrahydrofuran / 1 h / -78 °C

With lithium hydroxide; n-butyllithium; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; water;
DOI:10.1016/S0040-4039(00)76880-8

Reference yield:

: 16251-45-9,17097-67-5,28044-22-6,28044-23-7,39663-75-7,54418-69-8,77943-39-6,125133-96-2,149055-02-7
(4S,5R)-4-methyl-5-phenyl-oxazolidin-2-one

: 171847-71-5
C₁₃H₂₂O₅

: 157555-77-6
(4S,5R)-3-<(S)-2,2-dimethyl-1,3-dioxolane-4-propanoyl>-4-methyl-5-phenyl-2-oxazolidinone

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Yield given;
DOI:10.1016/S0040-4039(00)76880-8

Reference yield:

: 90472-93-8
methyl 3-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]propanoate

: 157555-77-6
(4S,5R)-3-<(S)-2,2-dimethyl-1,3-dioxolane-4-propanoyl>-4-methyl-5-phenyl-2-oxazolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / LiOH / methanol; H₂O / 48 h / Ambient temperature

2: Et₃N / tetrahydrofuran / -78 °C

3: n-BuLi / tetrahydrofuran / 1 h / -78 °C

With lithium hydroxide; n-butyllithium; triethylamine; In tetrahydrofuran; methanol; water;
DOI:10.1016/S0040-4039(00)76880-8