Technology Process of 3-isopropoxy-5,5-dimethyl-6-<2-(2-isopropyl-3,4-cyclohexylidenedioxy)phenyl>ethyl-2-cyclohexenone
There total 6 articles about 3-isopropoxy-5,5-dimethyl-6-<2-(2-isopropyl-3,4-cyclohexylidenedioxy)phenyl>ethyl-2-cyclohexenone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium cyanoborohydride;
In
diethyl ether;
at 80 ℃;
for 12h;
Yield given;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 75 percent / NBS / CH2Cl2 / 4 h / 0 - 10 °C
2: 1.) n-BuLi / 1.) THF, Et2O, -78 deg C, 40 min, 2.) THF, Et2O, -78 deg C, 1 h
3: 100 percent / I2, Ph3P, imidazole / acetonitrile; diethyl ether / 1 h
4: 1.) LDA / 1.) THF, -78 deg C, 40 min, 2.) THF, a) -78d eg C, 1 h, b) RT, overnight
With
1H-imidazole; N-Bromosuccinimide; n-butyllithium; iodine; triphenylphosphine; lithium diisopropyl amide;
In
diethyl ether; dichloromethane; acetonitrile;
DOI:10.1080/00397919308011185
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) n-BuLi / 1.) THF, Et2O, -78 deg C, 40 min, 2.) THF, Et2O, -78 deg C, 1 h
2: 100 percent / I2, Ph3P, imidazole / acetonitrile; diethyl ether / 1 h
3: 1.) LDA / 1.) THF, -78 deg C, 40 min, 2.) THF, a) -78d eg C, 1 h, b) RT, overnight
With
1H-imidazole; n-butyllithium; iodine; triphenylphosphine; lithium diisopropyl amide;
In
diethyl ether; acetonitrile;
DOI:10.1080/00397919308011185
