(12-{(R)-2-[(R)-1-(12-tert-Butoxycarbonylamino-dodecyloxymethyl)-2-trityloxy-ethoxymethoxy]-3-trityloxy-propoxy}-dodecyl)-carbamic acid tert-butyl ester

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Chemical Name:(12-{(R)-2-[(R)-1-(12-tert-Butoxycarbonylamino-dodecyloxymethyl)-2-trityloxy-ethoxymethoxy]-3-trityloxy-propoxy}-dodecyl)-carbamic acid tert-butyl ester
CAS No.:154371-98-9
Molecular Formula:C₇₉H₁₁₀N₂O₁₀
Molecular Weight:1247.75
Hs Code.:

(12-{(R)-2-[(R)-1-(12-tert-Butoxycarbonylamino-dodecyloxymethyl)-2-trityloxy-ethoxymethoxy]-3-trityloxy-propoxy}-dodecyl)-carbamic acid tert-butyl ester

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Chemical Property of (12-{(R)-2-[(R)-1-(12-tert-Butoxycarbonylamino-dodecyloxymethyl)-2-trityloxy-ethoxymethoxy]-3-trityloxy-propoxy}-dodecyl)-carbamic acid tert-butyl ester

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Technology Process of (12-{(R)-2-[(R)-1-(12-tert-Butoxycarbonylamino-dodecyloxymethyl)-2-trityloxy-ethoxymethoxy]-3-trityloxy-propoxy}-dodecyl)-carbamic acid tert-butyl ester

There total 11 articles about (12-{(R)-2-[(R)-1-(12-tert-Butoxycarbonylamino-dodecyloxymethyl)-2-trityloxy-ethoxymethoxy]-3-trityloxy-propoxy}-dodecyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1611-56-9
1-Bromo-11-hydroxyundecane

: 154371-98-9
(12-{(R)-2-[(R)-1-(12-tert-Butoxycarbonylamino-dodecyloxymethyl)-2-trityloxy-ethoxymethoxy]-3-trityloxy-propoxy}-dodecyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / dimethylsulfoxide / 0.5 h / 90 °C

2: 74 percent / sodium aluminum bis-(2-methoxyethoxo)-dihydrode (Vitrid) / diethyl ether; toluene / 2 h / Heating

3: 99 percent / Et₃N / tetrahydrofuran / 2 h / Ambient temperature

4: 89 percent / Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

5: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 5 h

With sodium hydride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1016/0009-3084(93)90036-3

Reference yield:

: 67107-87-3
12-aminododecan-1-ol

: 154371-98-9
(12-{(R)-2-[(R)-1-(12-tert-Butoxycarbonylamino-dodecyloxymethyl)-2-trityloxy-ethoxymethoxy]-3-trityloxy-propoxy}-dodecyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / Et₃N / tetrahydrofuran / 2 h / Ambient temperature

2: 89 percent / Et₃N / CH₂Cl₂ / 0.5 h / Ambient temperature

3: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 5 h

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/0009-3084(93)90036-3

Reference yield:

: 36566-49-1
(4R,5R,6R,7R)-4,7-bis(hydroxymethyl)-1,3-dioxepane-5,6-diol

: 154371-98-9
(12-{(R)-2-[(R)-1-(12-tert-Butoxycarbonylamino-dodecyloxymethyl)-2-trityloxy-ethoxymethoxy]-3-trityloxy-propoxy}-dodecyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / pyridine / 1 h / Ambient temperature

2: NaIO₄ / H₂O; ethanol / 3 h / Ambient temperature

3: NaBH₄ / H₂O; ethanol / 2 h / 0 °C

4: Et₃N / butan-1-ol / 3 h / Heating

5: NaOMe / methanol / 2 h / Heating

6: 1.) NaH / 1.) DMF, 30 min, 2.) DMF, RT, 5 h

With pyridine; sodium tetrahydroborate; sodium periodate; sodium methylate; sodium hydride; triethylamine; In methanol; ethanol; water; butan-1-ol;
DOI:10.1016/0009-3084(93)90036-3