(S)-N-(tert-butoxycarbonylmethyl)-N-(2-hydroxyethyl)-N-(2-methoxybenzyl)-N-methylammonium bromide

Base Information

• Chemical Name: (S)-N-(tert-butoxycarbonylmethyl)-N-(2-hydroxyethyl)-N-(2-methoxybenzyl)-N-methylammonium bromide
• CAS No.: 1206549-03-2
• Molecular Formula: Br*C₁₇H₂₈NO₄
• Molecular Weight: 390.318
• Mol file: 1206549-03-2.mol

Synonyms:

Chemical Property of (S)-N-(tert-butoxycarbonylmethyl)-N-(2-hydroxyethyl)-N-(2-methoxybenzyl)-N-methylammonium bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(tert-butoxycarbonylmethyl)-N-(2-hydroxyethyl)-N-(2-methoxybenzyl)-N-methylammonium bromide

There total 3 articles about (S)-N-(tert-butoxycarbonylmethyl)-N-(2-hydroxyethyl)-N-(2-methoxybenzyl)-N-methylammonium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

bromoacetic acid tert-butyl ester (5292-43-3) + N-(2-hydroxyethyl)-N-(2-methoxylbenzyl)methylamine (100054-98-6) → N-(tert-butoxycarbonylmethyl)-N-(2-hydroxyethyl)-N-(2-methoxybenzyl)-N-methylammonium bromide (1206549-03-2)

Guidance literature:

In acetonitrile; at 20 ℃; for 48h;

DOI:10.1016/j.tetasy.2009.10.025

Reference yield:

N-(tert-butoxycarbonylmethyl)-N-(2-hydroxyethyl)-N-(2-methoxybenzyl)-N-methylammonium bromide (1206549-03-2) → (R)-N-(tert-butoxycarbonylmethyl)-N-(2-hydroxyethyl)-N-(2-methoxybenzyl)-N-methylammonium bromide (1206549-03-2) + (S)-N-(tert-butoxycarbonylmethyl)-N-(2-hydroxyethyl)-N-(2-methoxybenzyl)-N-methylammonium bromide (1206549-03-2)

Guidance literature:

N-(tert-butoxycarbonylmethyl)-N-(2-hydroxyethyl)-N-(2-methoxybenzyl)-N-methylammonium bromide; With (S)-[1,1']-binaphthalenyl-2,2'-diol; In dichloromethane; at 20 ℃; for 24h; Resolution of racemate;

With water; In methanol; diethyl ether; optical yield given as %ee;

DOI:10.1016/j.tetasy.2009.10.025

Reference yield:

N-(tert-butoxycarbonylmethyl)-N-(2-hydroxyethyl)-N-(2-methoxybenzyl)-N-methylammonium bromide (1206549-03-2) → (R)-N-(tert-butoxycarbonylmethyl)-N-(2-hydroxyethyl)-N-(2-methoxybenzyl)-N-methylammonium bromide (1206549-03-2) + (S)-N-(tert-butoxycarbonylmethyl)-N-(2-hydroxyethyl)-N-(2-methoxybenzyl)-N-methylammonium bromide (1206549-03-2)

Guidance literature:

N-(tert-butoxycarbonylmethyl)-N-(2-hydroxyethyl)-N-(2-methoxybenzyl)-N-methylammonium bromide; With (S)-[1,1']-binaphthalenyl-2,2'-diol; In dichloromethane; at 20 ℃; for 24h; Resolution of racemate;

With water; In methanol; diethyl ether; optical yield given as %ee;

DOI:10.1016/j.tetasy.2009.10.025

upstream raw materials:

bromoacetic acid tert-butyl ester

N-(2-hydroxyethyl)-N-(2-methoxylbenzyl)methylamine

Downstream raw materials:

(S)-3-(2-methoxybenzyl)-4-methylmorpholin-2-one