1L-2-O-[(tert-butyl)dimethylsilyl]-1,3,5-O-methylidyne-4-O-{((R)-1-phenylethyl)[((R)-1-phenylethyl)carbamoyl]carbamoyl}-1,2,3,5/4-cyclohexanepentol

Base Information

Chemical Name:1L-2-O-[(tert-butyl)dimethylsilyl]-1,3,5-O-methylidyne-4-O-{((R)-1-phenylethyl)[((R)-1-phenylethyl)carbamoyl]carbamoyl}-1,2,3,5/4-cyclohexanepentol
CAS No.:181138-30-7
Molecular Formula:C₃₁H₄₂N₂O₇Si
Molecular Weight:582.769
Hs Code.:

1L-2-O-[(tert-butyl)dimethylsilyl]-1,3,5-O-methylidyne-4-O-{((R)-1-phenylethyl)[((R)-1-phenylethyl)carbamoyl]carbamoyl}-1,2,3,5/4-cyclohexanepentol

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Chemical Property of 1L-2-O-[(tert-butyl)dimethylsilyl]-1,3,5-O-methylidyne-4-O-{((R)-1-phenylethyl)[((R)-1-phenylethyl)carbamoyl]carbamoyl}-1,2,3,5/4-cyclohexanepentol

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Technology Process of 1L-2-O-[(tert-butyl)dimethylsilyl]-1,3,5-O-methylidyne-4-O-{((R)-1-phenylethyl)[((R)-1-phenylethyl)carbamoyl]carbamoyl}-1,2,3,5/4-cyclohexanepentol

There total 3 articles about 1L-2-O-[(tert-butyl)dimethylsilyl]-1,3,5-O-methylidyne-4-O-{((R)-1-phenylethyl)[((R)-1-phenylethyl)carbamoyl]carbamoyl}-1,2,3,5/4-cyclohexanepentol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33375-06-3
(1R)-1-phenylethyl isocyanate

: (1R,3S,5S,6R,7S,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-2,4,10-trioxa-tricyclo[3.3.1.1^3,7]decan-6-ol

: ((R)-1-Phenyl-ethyl)-carbamic acid (1R,3S,5S,6R,7S,8R)-8-(tert-butyl-dimethyl-silanyloxy)-2,4,10-trioxa-tricyclo[3.3.1.1^3,7]dec-6-yl ester

: ((R)-1-Phenyl-ethyl)-carbamic acid (1S,3R,5R,6S,7R,8S)-8-(tert-butyl-dimethyl-silanyloxy)-2,4,10-trioxa-tricyclo[3.3.1.1^3,7]dec-6-yl ester

: 181138-30-7
1L-2-O-[(tert-butyl)dimethylsilyl]-1,3,5-O-methylidyne-4-O-{((R)-1-phenylethyl)[((R)-1-phenylethyl)carbamoyl]carbamoyl}-1,2,3,5/4-cyclohexanepentol

: 180895-51-6
1D-2-O-[(tert-butyl)dimethylsilyl]-1,3,5-O-methylidyne-4-O-{((R)-1-phenylethyl)[((R)-1-phenylethyl)carbamoyl]carbamoyl}-1,2,3,5/4-cyclohexanepentol

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1.16667h; Yield given. Yields of byproduct given;
DOI:10.1002/hlca.19960790424

Reference yield:

: 98510-22-6
(1R,3S,5S,6R,7S,8S,9S)-9-<(tert-butyl)dimethylsilyloxy>-2,4,10-tri-oxatricyclo<3.3.1.1^3,7>decane-6,8-diol

: 181138-30-7
1L-2-O-[(tert-butyl)dimethylsilyl]-1,3,5-O-methylidyne-4-O-{((R)-1-phenylethyl)[((R)-1-phenylethyl)carbamoyl]carbamoyl}-1,2,3,5/4-cyclohexanepentol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Bu₂SnO, 2.) PhOCSCl, 3.) Bu₃SnH, AIBN / 1.) MeOH, reflux, 3 h, 2.) dioxane, 12 h, r.t., 3.) toluene, reflux, 2 h

2: BuLi in hexane / tetrahydrofuran / 1.17 h / -78 °C

With n-butyllithium; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; di(n-butyl)tin oxide; phenylcarbonochloridothioate; In tetrahydrofuran;
DOI:10.1002/hlca.19960790424

Reference yield:

: 180895-48-1
2-O-[(tert-butyl)dimethylsilyl]-1,3,5-O-methylidyne-4,6-O-thiocarbonyl-myo-inositol

: 181138-30-7
1L-2-O-[(tert-butyl)dimethylsilyl]-1,3,5-O-methylidyne-4-O-{((R)-1-phenylethyl)[((R)-1-phenylethyl)carbamoyl]carbamoyl}-1,2,3,5/4-cyclohexanepentol

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / Bu₃SnH, AIBN / toluene / 1 h / Heating

2: BuLi in hexane / tetrahydrofuran / 1.17 h / -78 °C

With n-butyllithium; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; toluene;
DOI:10.1002/hlca.19960790424