Technology Process of C21H27NO2S
There total 6 articles about C21H27NO2S which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 0 ℃;
for 6h;
DOI:10.1039/c3cc40583d
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N-(((2S,4R)-4-(tert-butyldimethylsilyloxy)pyrrolidin-2-yl)methyl)-1,1,1-trifluoromethanesulfonamide / N,N-dimethyl-formamide / 0.25 h / 20 °C
1.2: 24 h / 0 °C
2.1: zinc; acetic acid / water / 1.5 h / 0 - 20 °C
2.2: pH 12
3.1: triethylamine / dichloromethane / 6 h / 0 °C
With
N-(((2S,4R)-4-(tert-butyldimethylsilyloxy)pyrrolidin-2-yl)methyl)-1,1,1-trifluoromethanesulfonamide; acetic acid; triethylamine; zinc;
In
dichloromethane; water; N,N-dimethyl-formamide;
1.2: |Michael Addition;
DOI:10.1039/c3cc40583d
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridine / dichloromethane
2.1: sodium acetate / tert-butyl methyl ether
3.1: 4-nitro-benzoic acid; N-(((2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl)methyl)-1,1,1-trifluoromethanesulfonamide / N,N-dimethyl-formamide / 0.25 h / 20 °C
3.2: 28 h / 0 °C
4.1: zinc; acetic acid / water / 1.5 h / 0 - 20 °C
4.2: pH 12
5.1: triethylamine / dichloromethane / 6 h / 0 °C
With
pyridine; N-(((2S,4R)-4-(tert-butyldiphenylsilyloxy)pyrrolidin-2-yl)methyl)-1,1,1-trifluoromethanesulfonamide; sodium acetate; acetic acid; triethylamine; zinc; 4-nitro-benzoic acid;
In
dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide;
3.2: |Michael Addition;
DOI:10.1039/c3cc40583d
