Methyl 3-[2-chloro-4-(trifluoromethyl)phenyl]acrylate, Methyl 3-[2-chloro-4-(trifluoromethyl)phenyl]prop-2-enoate

Base Information

• Chemical Name: Methyl 3-[2-chloro-4-(trifluoromethyl)phenyl]acrylate, Methyl 3-[2-chloro-4-(trifluoromethyl)phenyl]prop-2-enoate
• CAS No.: 243977-24-4
• Molecular Formula: C₁₁H₈ClF₃O₂
• Molecular Weight: 264.632
• Hs Code.: 2916399090
• Mol file: 243977-24-4.mol

Synonyms:

Chemical Property of Methyl 3-[2-chloro-4-(trifluoromethyl)phenyl]acrylate, Methyl 3-[2-chloro-4-(trifluoromethyl)phenyl]prop-2-enoate

Chemical Property:

Purity/Quality:

Methyl 2-chloro-4-(trifluoromethyl)cinnamate 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl 3-[2-chloro-4-(trifluoromethyl)phenyl]acrylate, Methyl 3-[2-chloro-4-(trifluoromethyl)phenyl]prop-2-enoate

There total 1 articles about Methyl 3-[2-chloro-4-(trifluoromethyl)phenyl]acrylate, Methyl 3-[2-chloro-4-(trifluoromethyl)phenyl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloro-4-(trifluoromethyl)-benzaldehyde (82096-91-1) + methyl (triphenylphosphoranylidene)acetate (21204-67-1,2605-67-6) → C11H8ClF3O2 (243977-24-4)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1021/acs.jmedchem.8b01972

Reference yield:

C11H8ClF3O2 (243977-24-4) → C17H19ClF3NO4

Guidance literature:

Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C

2: ammonium formate; palladium 10% on activated carbon / methanol / 0.5 h / 70 °C / Inert atmosphere

3: triethylamine / methanol / 16 h / 0 - 20 °C

4: lithium hydroxide; water / methanol / 4 h / 20 °C

With palladium 10% on activated carbon; water; ammonium formate; triethylamine; trifluoroacetic acid; lithium hydroxide; In methanol; dichloromethane;

DOI:10.1021/acs.jmedchem.8b01972

upstream raw materials:

2-chloro-4-(trifluoromethyl)-benzaldehyde

methyl (triphenylphosphoranylidene)acetate