Technology Process of methyl 3α-acetoxy-7-oxo-5β-cholanoic acid
There total 1 articles about methyl 3α-acetoxy-7-oxo-5β-cholanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
7α-Hydroxy-3α-acetoxy-5β-cholansaeure-methylester, CrO3-H2SO4;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: acetic acid; bromine / 20 h / 20 °C
2: sodium tetrahydroborate / dichloromethane; methanol / 0.33 h / 20 °C
3: acetic acid; zinc / 0.5 h / Reflux
4: 3-chloro-benzenecarboperoxoic acid; Santonox R / 1,2-dichloro-ethane / 2 h / Reflux
5: boron trifluoride diethyl etherate / N,N-dimethyl-formamide / 16 h / 20 °C
6: potassium hydroxide / methanol / 2 h / Reflux
7: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 20 h / 20 °C
With
sodium tetrahydroborate; Santonox R; boron trifluoride diethyl etherate; bromine; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; zinc;
In
methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.5012/bkcs.2013.34.8.2436
- Guidance literature:
-
Multi-step reaction with 4 steps
1: acetic acid; bromine / 20 h / 20 °C
2: potassium hydroxide / methanol / 20 °C
3: sulfuric acid / 3 h / Reflux
4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane; N,N-dimethyl-formamide / 20 h / 20 °C
With
sulfuric acid; bromine; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.5012/bkcs.2013.34.8.2436
