6-AMino-1,3-dibutyl-5-nitroso-2,4(1H,3H)-pyriMidinedione

Base Information

• Chemical Name: 6-AMino-1,3-dibutyl-5-nitroso-2,4(1H,3H)-pyriMidinedione
• CAS No.: 132716-86-0
• Molecular Formula: C12H20N4O3
• Molecular Weight: 268.316
• Hs Code.: 2933599090
• Mol file: 132716-86-0.mol

Synonyms:1,3-Dibutyl-5-nitroso-6-amino-uracil;6-amino-1,3-dibutyl-5-nitroso-1,2,3,4-tetrahydropyrimidine-2,4-dione;6-amino-1,3-dibutyl-5-nitroso-1H-pyrimidine-2,4-dione;6-amino-1,3-di-n-butyl-5-nitroso-uracil;6-amino-1,3-dibutyl-5-nitrosouracil;6-Amino-1,3-dibutyl-5-nitroso-1H-pyrimidin-2,4-dion;

Chemical Property of 6-AMino-1,3-dibutyl-5-nitroso-2,4(1H,3H)-pyriMidinedione

Chemical Property:

• Melting Point: 206-208°C
• PSA: 99.45000
• LogP: 2.17150
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Dichloromethane, DMSO, Methanol

Purity/Quality:

NLT 98% ^*data from raw suppliers

6-Amino-1,3-dibutyl-5-nitroso-2,4(1H,3H)-pyrimidinedione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of disubstituted Xanthine derivatives.

Technology Process of 6-AMino-1,3-dibutyl-5-nitroso-2,4(1H,3H)-pyriMidinedione

There total 4 articles about 6-AMino-1,3-dibutyl-5-nitroso-2,4(1H,3H)-pyriMidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.6%

6-Amino-1,3-dibutylpyrimidine-2,4(1H,3H)-dione (41862-16-2) → 6-amino-1,3-di-n-butyl-5-nitroso-uracil (132716-86-0)

Guidance literature:

With hydrogenchloride; acetic acid; sodium nitrite; In water; for 0.5h;

DOI:10.1021/jm00046a022

Reference yield:

N,N'-di-n-butylurea (1792-17-2) → 6-amino-1,3-di-n-butyl-5-nitroso-uracil (132716-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Ac₂O / 70 °C

2.1: aq. AcOH / 0.5 h / 75 °C

2.2: NaNO₂ / 1 h / 20 °C

With acetic anhydride; acetic acid;

DOI:10.1021/jm051268+

Reference yield:

N,N-di-n-butylurea (161419-76-7) → 6-amino-1,3-di-n-butyl-5-nitroso-uracil (132716-86-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / methanol / 0.5 h

2: 82.6 percent / glacial acetic acid, aq. HCl, NaNO₂ / H₂O / 0.5 h

With hydrogenchloride; sodium hydroxide; acetic acid; sodium nitrite; In methanol; water;

DOI:10.1021/jm00046a022

upstream raw materials:

6-Amino-1,3-dibutylpyrimidine-2,4(1H,3H)-dione

N,N'-di-n-butylurea

N,N-di-n-butylurea

Downstream raw materials:

1,3-di-n-butyl-5,6-diamino-uracil

5,6-diaminouracil

1,3-dibutylxanthine