4-(5-amino-1H-1,2,4-triazol-3-ylamino)-2-cyclopropylbenzonitrile

Base Information

Chemical Name:4-(5-amino-1H-1,2,4-triazol-3-ylamino)-2-cyclopropylbenzonitrile
CAS No.:1533424-23-5
Molecular Formula:C₁₂H₁₂N₆
Molecular Weight:240.267
Hs Code.:

Synonyms:

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Chemical Property of 4-(5-amino-1H-1,2,4-triazol-3-ylamino)-2-cyclopropylbenzonitrile

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Technology Process of 4-(5-amino-1H-1,2,4-triazol-3-ylamino)-2-cyclopropylbenzonitrile

There total 4 articles about 4-(5-amino-1H-1,2,4-triazol-3-ylamino)-2-cyclopropylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1006899-23-5
4-amino-2-cyclopropylbenzonitrile

: 1533424-23-5
4-(5-amino-1H-1,2,4-triazol-3-ylamino)-2-cyclopropylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 12 h / 20 °C / 760.05 Torr / Inert atmosphere

2.1: sodium methylate / methanol / 0.25 h / 20 °C / 760.05 Torr / Inert atmosphere

2.2: 1 h / 20 °C / 760.05 Torr / Inert atmosphere

2.3: 20 °C / 760.05 Torr / Inert atmosphere

3.1: hydrazine / ethanol / 20 °C / 760.05 Torr / Reflux; Inert atmosphere

With sodium methylate; hydrazine; In methanol; ethanol; dichloromethane;

Reference yield:

: 1533425-13-6
2-cyclopropyl-4-isothiocyanatobenzonitrile

: 1533424-23-5
4-(5-amino-1H-1,2,4-triazol-3-ylamino)-2-cyclopropylbenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium methylate / methanol / 0.25 h / 20 °C / 760.05 Torr / Inert atmosphere

1.2: 1 h / 20 °C / 760.05 Torr / Inert atmosphere

1.3: 20 °C / 760.05 Torr / Inert atmosphere

2.1: hydrazine / ethanol / 20 °C / 760.05 Torr / Reflux; Inert atmosphere

With sodium methylate; hydrazine; In methanol; ethanol;

Reference yield:

: 28163-00-0
4-nitro-2-chlorobenzonitrile

: 1533424-23-5
4-(5-amino-1H-1,2,4-triazol-3-ylamino)-2-cyclopropylbenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: XPhos; potassium carbonate; palladium diacetate / water; tetrahydrofuran / 16 h / 75 °C / 760.05 Torr / Inert atmosphere

2.1: iron; ammonium chloride / methanol; water / 13 h / 50 - 75 °C / 760.05 Torr / Inert atmosphere

3.1: dichloromethane / 12 h / 20 °C / 760.05 Torr / Inert atmosphere

4.1: sodium methylate / methanol / 0.25 h / 20 °C / 760.05 Torr / Inert atmosphere

4.2: 1 h / 20 °C / 760.05 Torr / Inert atmosphere

4.3: 20 °C / 760.05 Torr / Inert atmosphere

5.1: hydrazine / ethanol / 20 °C / 760.05 Torr / Reflux; Inert atmosphere

With sodium methylate; palladium diacetate; iron; potassium carbonate; ammonium chloride; hydrazine; XPhos; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;