Cefixime anhydrous, (E)-

Base Information

Chemical Name:Cefixime anhydrous, (E)-
CAS No.:97164-56-2
Molecular Formula:C₁₆H₁₅N₅O₇S₂
Molecular Weight:453.456
Hs Code.:
European Community (EC) Number:616-684-4
UNII:U7RWT9J78O
Nikkaji Number:J22.201A
Wikipedia:Cefixime
Wikidata:Q163901
NCI Thesaurus Code:C1100
RXCUI:25033
ChEMBL ID:CHEMBL427069
Mol file:97164-56-2.mol

Synonyms:Cefixime;Cefixime Anhydrous;Cefixime Trihydrate;FK 027;FK-027;FK027;FR 17027;FR-17027;FR17027;Suprax

Suppliers and Price of Cefixime anhydrous, (E)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(E)-Cefixime(CefiximeEPImpurityD)
10mg
$ 9625.00

Biosynth Carbosynth
Cefixime impurity D
100 mg
$ 8500.00

Biosynth Carbosynth
Cefixime impurity D
50 mg
$ 5250.00

Biosynth Carbosynth
Cefixime impurity D
25 mg
$ 3250.00

Biosynth Carbosynth
Cefixime impurity D
10 mg
$ 2000.00

Biosynth Carbosynth
Cefixime impurity D
5 mg
$ 1500.00

Total 14 raw suppliers

Chemical Property of Cefixime anhydrous, (E)-

Chemical Property:

PKA:2.80±0.50(Predicted)
Density:1.85±0.1 g/cm3(Predicted)
XLogP3:-0.7
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:12
Rotatable Bond Count:8
Exact Mass:453.04129018
Heavy Atom Count:30
Complexity:861

Purity/Quality:

98%,99%, ^*data from raw suppliers

(E)-Cefixime(CefiximeEPImpurityD) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C=CC1=C(N2C(C(C2=O)NC(=O)C(=NOCC(=O)O)C3=CSC(=N3)N)SC1)C(=O)O
Isomeric SMILES:C=CC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)/C(=N/OCC(=O)O)/C3=CSC(=N3)N)SC1)C(=O)O
Recent ClinicalTrials:The Azithromycin and Cefixime Treatment of Typhoid in South Asia Trial (ACT-South Asia Trial)
Recent EU Clinical Trials:3-day intravenous antibiotic treatment versus 3-day intravenous followed by 7-day oral antibiotic treatment for acute pyelonephritis in children 1 month to 3 years old: a non-inferiority open randomized multicentric clinical trial
Uses (E)-Cefixime is an isomeric impurity of the third generation cephalosporin antibiotic, Cefixime (C242800).

Technology Process of Cefixime anhydrous, (E)-

There total 10 articles about Cefixime anhydrous, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.2%

: 79350-36-0,108908-53-8
diphenylmethyl 7β-<(E)-2-(2-amino-4-thiazolyl)-2-tert-butoxycarbonylmethoxyiminoacetamido>-3-vinyl-3-cephem-4-carboxylate

: 79350-37-1,97164-56-2,97590-26-6,108691-83-4,116173-42-3
7β-<(E)-2-(2-amino-4-thiazolyl)-2-carboxymethoxyiminoacetamido>-3-vinyl-3-cephem-4-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.5h;
DOI:10.1248/cpb.34.3458

Reference yield: 62.1%

: 95759-14-1,108908-52-7
7β-<(E)-2-(2-amino-4-thiazolyl)-2-p-nitrobenzyloxycarbonylmethoxyiminoacetamido>-3-vinyl-3-cephem-4-carboxylic acid

: 79350-37-1,97164-56-2,97590-26-6,108691-83-4,116173-42-3
7β-<(E)-2-(2-amino-4-thiazolyl)-2-carboxymethoxyiminoacetamido>-3-vinyl-3-cephem-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In water; for 0.0833333h;
DOI:10.1248/cpb.34.3458

Reference yield:

: 68401-68-3
2-(tert-butoxycarbonylmethoxyimino)-2-(2-formamidothiazol-4-yl)acetic acid

: 79350-37-1,97164-56-2,97590-26-6,108691-83-4,116173-42-3
7β-<(E)-2-(2-amino-4-thiazolyl)-2-carboxymethoxyiminoacetamido>-3-vinyl-3-cephem-4-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 23.8 percent / thionyl chloride / CHCl₃ / 2.5 h / Heating

2: 1.) POCl₃, DMF; 2.) N-(trimethylsilyl)acetamide / 1.) EtOAc, 0-5 deg C, 30 min; 2.) THF, -20- -30 deg C, 30 min

3: 91.7 percent / conc. HCl / methanol; tetrahydrofuran / 4 h / Ambient temperature

4: 66.2 percent / TFA / CH₂Cl₂; various solvent(s) / 0.5 h

With hydrogenchloride; thionyl chloride; N,N-dimethyl-formamide; N-Trimethylsilylacetamide; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; chloroform;
DOI:10.1248/cpb.34.3458