Technology Process of (E)-2-fluorocyclohexanone (S)-(-)-(1-methoxy-3-phenylprop-2-yl)imine
There total 12 articles about (E)-2-fluorocyclohexanone (S)-(-)-(1-methoxy-3-phenylprop-2-yl)imine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thionyl chloride / 1.) 20 deg C, 2 h, 2.) reflux, 2 h
2: sodium borohydride / ethanol; H2O / 4 h / Heating
3: 1.) potassium hydride / 1.) THF, overnight, 2.) THF, 1 min
4: activated 4A molecular sieves / CCl4 / Ambient temperature
With
sodium tetrahydroborate; thionyl chloride; 4 A molecular sieve; potassium hydride;
In
tetrachloromethane; ethanol; water;
DOI:10.1021/jo00248a017
- Guidance literature:
-
Multi-step reaction with 4 steps
1: thionyl chloride / 1.) 20 deg C, 2 h, 2.) reflux, 2 h
2: sodium borohydride / ethanol; H2O / 4 h / Heating
3: 1.) potassium hydride / 1.) THF, overnight, 2.) THF, 1 min
4: activated 4A molecular sieves / CCl4 / Ambient temperature
With
sodium tetrahydroborate; thionyl chloride; 4 A molecular sieve; potassium hydride;
In
tetrachloromethane; ethanol; water;
DOI:10.1021/jo00248a017
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 77 percent / Jones' reagent / acetone
2: activated 4A molecular sieves / CCl4 / Ambient temperature
With
jones' reagent; 4 A molecular sieve;
In
tetrachloromethane; acetone;
DOI:10.1021/jo00248a017
