(7R,6R)-7-[2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-(Z)-trityloxyimino-acetylamino]-3-[2-(2-tert-butoxycarbonylamino-ethylsulfanylmethyl)-pyridin-3-ylsulfanyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tertbutyl ester

Base Information

Chemical Name:(7R,6R)-7-[2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-(Z)-trityloxyimino-acetylamino]-3-[2-(2-tert-butoxycarbonylamino-ethylsulfanylmethyl)-pyridin-3-ylsulfanyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tertbutyl ester
CAS No.:331780-46-2
Molecular Formula:C₄₇H₅₀N₈O₇S₄
Molecular Weight:967.227
Hs Code.:

(7R,6R)-7-[2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-(Z)-trityloxyimino-acetylamino]-3-[2-(2-tert-butoxycarbonylamino-ethylsulfanylmethyl)-pyridin-3-ylsulfanyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tertbutyl ester

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Chemical Property of (7R,6R)-7-[2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-(Z)-trityloxyimino-acetylamino]-3-[2-(2-tert-butoxycarbonylamino-ethylsulfanylmethyl)-pyridin-3-ylsulfanyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tertbutyl ester

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Technology Process of (7R,6R)-7-[2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-(Z)-trityloxyimino-acetylamino]-3-[2-(2-tert-butoxycarbonylamino-ethylsulfanylmethyl)-pyridin-3-ylsulfanyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tertbutyl ester

There total 5 articles about (7R,6R)-7-[2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-(Z)-trityloxyimino-acetylamino]-3-[2-(2-tert-butoxycarbonylamino-ethylsulfanylmethyl)-pyridin-3-ylsulfanyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tertbutyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 331780-08-6
(2-{3-[2-(2-tert-butoxycarbonylamino-ethylsulfanylmethyl)-pyridin-3-yldisulfanyl]-pyridin-2-ylmethylsulfanyl}-ethyl)-carbamic acid tert-butyl ester

: 331780-41-7
(6R,7R)-7-[2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-(Z)-trityloxyimino-acetylamino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

: 331780-46-2
(7R,6R)-7-[2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-(Z)-trityloxyimino-acetylamino]-3-[2-(2-tert-butoxycarbonylamino-ethylsulfanylmethyl)-pyridin-3-ylsulfanyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tertbutyl ester

Guidance literature:: With sodium hydrogencarbonate; triphenylphosphine; In water; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0968-0896(02)00431-5

Reference yield:

: 53994-69-7
(6R,7R)-1-aza-3-chloro-7-amino-8-oxo-5-thiabicyclo<4.2.0>oct-2-ene-2-carboxylic acid

: 331780-46-2
(7R,6R)-7-[2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-(Z)-trityloxyimino-acetylamino]-3-[2-(2-tert-butoxycarbonylamino-ethylsulfanylmethyl)-pyridin-3-ylsulfanyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tertbutyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 52 percent / BF₃*Et₂O / 20 °C

2.1: diphenylchlorophosphonate / tetrahydrofuran / 1 h / 20 °C

2.2: 14.1 percent / 2,6-lutidine / tetrahydrofuran / 3 h / 20 °C

3.1: 2.91 g / triphenylphosphine; NaHCO₃ / H₂O; dimethylformamide / 20 °C

With boron trifluoride diethyl etherate; sodium hydrogencarbonate; triphenylphosphine; chlorophosphoric acid diphenyl ester; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00431-5

Reference yield:

: 331780-40-6
(7R,6R)-7-amino-3-chloro-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

: 331780-46-2
(7R,6R)-7-[2-(5-amino-[1,2,4]thiadiazol-3-yl)-2-(Z)-trityloxyimino-acetylamino]-3-[2-(2-tert-butoxycarbonylamino-ethylsulfanylmethyl)-pyridin-3-ylsulfanyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tertbutyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: diphenylchlorophosphonate / tetrahydrofuran / 1 h / 20 °C

1.2: 14.1 percent / 2,6-lutidine / tetrahydrofuran / 3 h / 20 °C

2.1: 2.91 g / triphenylphosphine; NaHCO₃ / H₂O; dimethylformamide / 20 °C

With sodium hydrogencarbonate; triphenylphosphine; chlorophosphoric acid diphenyl ester; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00431-5