Technology Process of 3-(1,3-BENZODIOXOL-5-YL)-N,N-DIBENZYLACRYLAMIDE
There total 2 articles about 3-(1,3-BENZODIOXOL-5-YL)-N,N-DIBENZYLACRYLAMIDE which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-methylpropan-2-aminium 3-(dibenzylamino)-3-oxopropanoate;
With
citric acid;
In
water; ethyl acetate;
for 0.5h;
Inert atmosphere;
Schlenk technique;
piperonal;
With
acetic acid;
In
N,N-dimethyl acetamide;
for 16h;
Inert atmosphere;
Schlenk technique;
DOI:10.1021/acs.joc.9b00450
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine; chloro-trimethyl-silane / dichloromethane / 0.5 h / Inert atmosphere; Schlenk technique; Reflux
1.2: 1 h / 20 °C / Inert atmosphere; Schlenk technique
1.3: 12 h / 20 - 30 °C / Inert atmosphere; Schlenk technique
2.1: citric acid / ethyl acetate; water / 0.5 h / Inert atmosphere; Schlenk technique
2.2: 16 h / Inert atmosphere; Schlenk technique
With
chloro-trimethyl-silane; triethylamine; citric acid;
In
dichloromethane; water; ethyl acetate;
DOI:10.1021/acs.joc.9b00450
