(4-chlorophenyl)cyclopentylhydroxyacetic acid

Base Information

• Chemical Name: (4-chlorophenyl)cyclopentylhydroxyacetic acid
• CAS No.: 92021-41-5
• Molecular Formula: C₁₃H₁₅ClO₃
• Molecular Weight: 254.713
• Mol file: 92021-41-5.mol

Synonyms:

Chemical Property of (4-chlorophenyl)cyclopentylhydroxyacetic acid

Chemical Property:

• Boiling Point: 423.9±30.0 °C(Predicted)
• Density: 1.351±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Chlorophenyl)-2-cyclopentyl-2-hydroxyaceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-chlorophenyl)cyclopentylhydroxyacetic acid

There total 4 articles about (4-chlorophenyl)cyclopentylhydroxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-(4-chlorophenyl)-2-cyclopentyl-2-hydroxyacetate (741682-85-9) → (4-chlorophenyl)cyclopentylhydroxyacetic acid (92021-41-5)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; for 18h; Reflux; Inert atmosphere;

DOI:10.1021/op3001788

Reference yield:

cyclopentyl-oxo-acetic acid ethyl ester (33537-18-7) → (4-chlorophenyl)cyclopentylhydroxyacetic acid (92021-41-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; diethyl ether / 1.5 h / Inert atmosphere

2: lithium hydroxide; water / tetrahydrofuran; methanol / 18 h / Reflux; Inert atmosphere

With water; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether;

DOI:10.1021/op3001788

Reference yield:

(4-chlorphenyl)magnesium bromide (873-77-8) → (4-chlorophenyl)cyclopentylhydroxyacetic acid (92021-41-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; diethyl ether / 1.5 h / Inert atmosphere

2: lithium hydroxide; water / tetrahydrofuran; methanol / 18 h / Reflux; Inert atmosphere

With water; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether;

DOI:10.1021/op3001788

upstream raw materials:

cyclopentyl-oxo-acetic acid ethyl ester

(4-chlorphenyl)magnesium bromide

ethyl 2-(4-chlorophenyl)-2-cyclopentyl-2-hydroxyacetate