2-tert-butoxycarbonylmethoxy-5-(2-(tert-butoxyoxalyl-amino)-2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:2-tert-butoxycarbonylmethoxy-5-(2-(tert-butoxyoxalyl-amino)-2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester
CAS No.:220193-85-1
Molecular Formula:C₅₁H₇₁N₅O₁₂Si
Molecular Weight:974.237
Hs Code.:

2-<i>tert</i>-butoxycarbonylmethoxy-5-(2-(<i>tert</i>-butoxyoxalyl-amino)-2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of 2-tert-butoxycarbonylmethoxy-5-(2-(tert-butoxyoxalyl-amino)-2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of 2-tert-butoxycarbonylmethoxy-5-(2-(tert-butoxyoxalyl-amino)-2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester

There total 4 articles about 2-tert-butoxycarbonylmethoxy-5-(2-(tert-butoxyoxalyl-amino)-2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220193-52-2
(2S)-2-amino-N₁-[3-(1-naphthalenyl)propyl]butanediamide

: 220193-85-1
2-tert-butoxycarbonylmethoxy-5-(2-(tert-butoxyoxalyl-amino)-2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) DIPCDI, HOBT*H₂O / 1.) DMF, RT, 10 min, 2.) DMF, RT, overnight

2: piperidine / acetonitrile / 1 h / Ambient temperature

3: 1.) HOBT*H₂O, DIPCDI / 1.) DMF, 2.) DMF, overnight

With piperidine; 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; In acetonitrile;
DOI:10.1021/jm980388x

Reference yield:

: 220193-51-1
{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexyl}-carbamic acid tert-butyl ester

: 220193-85-1
2-tert-butoxycarbonylmethoxy-5-(2-(tert-butoxyoxalyl-amino)-2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: TFA, triethylsilane / 1 h / Ambient temperature

2: 1.) DIPCDI, HOBT*H₂O / 1.) DMF, RT, 10 min, 2.) DMF, RT, overnight

3: piperidine / acetonitrile / 1 h / Ambient temperature

4: 1.) HOBT*H₂O, DIPCDI / 1.) DMF, 2.) DMF, overnight

With piperidine; triethylsilane; 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; trifluoroacetic acid; In acetonitrile;
DOI:10.1021/jm980388x

Reference yield:

: 220193-64-6
2-tert-butoxycarbonylmethoxy-5-[2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-benzoic acid 2-trimethylsilanyl-ethyl ester

: 220193-85-1
2-tert-butoxycarbonylmethoxy-5-(2-(tert-butoxyoxalyl-amino)-2-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-ethyl)-benzoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / acetonitrile / 1 h / Ambient temperature

2: 1.) HOBT*H₂O, DIPCDI / 1.) DMF, 2.) DMF, overnight

With piperidine; 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; In acetonitrile;
DOI:10.1021/jm980388x