(Rc, RpSp)-methyl [1-(methoxy)phenylmethyl]phosphonochloridate

Base Information

• Chemical Name: (Rc, RpSp)-methyl [1-(methoxy)phenylmethyl]phosphonochloridate
• CAS No.: 1338244-48-6
• Molecular Formula: C₉H₁₂ClO₃P
• Molecular Weight: 234.619
• Mol file: 1338244-48-6.mol

Synonyms:

Chemical Property of (Rc, RpSp)-methyl [1-(methoxy)phenylmethyl]phosphonochloridate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Rc, RpSp)-methyl [1-(methoxy)phenylmethyl]phosphonochloridate

There total 5 articles about (Rc, RpSp)-methyl [1-(methoxy)phenylmethyl]phosphonochloridate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl 1-hydroxy-1-phenylmethylphosphonate (6329-46-0,79296-54-1,97995-93-2,147731-04-2) → (Rc, RpSp)-methyl [1-(methoxy)phenylmethyl]phosphonochloridate (1338244-48-6)

Guidance literature:

Multi-step reaction with 5 steps

1: dmap; potassium carbonate / ethyl acetate / 20 °C

2: lipase FAP 15 / hexane; tert-butyl methyl ether / pH 7 / aq. phosphate buffer; Enzymatic reaction

3: acetic acid; silver(l) oxide / Darkness

4: sodium iodide / acetone / 22 h / Reflux

5: oxalyl dichloride / dichloromethane / 18.5 h / Reflux; Inert atmosphere

With dmap; oxalyl dichloride; lipase FAP 15; potassium carbonate; acetic acid; sodium iodide; silver(l) oxide; In hexane; dichloromethane; tert-butyl methyl ether; ethyl acetate; acetone;

DOI:10.1002/adsc.201100459

Reference yield:

(R)-dimethyl [1-(methoxy)phenylmethyl]phosphonate (1338244-46-4) → (Rc, RpSp)-methyl [1-(methoxy)phenylmethyl]phosphonochloridate (1338244-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide / acetone / 22 h / Reflux

2: oxalyl dichloride / dichloromethane / 18.5 h / Reflux; Inert atmosphere

With oxalyl dichloride; sodium iodide; In dichloromethane; acetone;

DOI:10.1002/adsc.201100459

Reference yield:

(Rc, RpSp)-methyl [1-(methoxy)phenylmethyl]phosphonate (1338244-47-5) → (Rc, RpSp)-methyl [1-(methoxy)phenylmethyl]phosphonochloridate (1338244-48-6)

Guidance literature:

With oxalyl dichloride; In dichloromethane; for 18.5h; Reflux; Inert atmosphere;

DOI:10.1002/adsc.201100459

upstream raw materials:

(R)-dimethyl [1-(methoxy)phenylmethyl]phosphonate

(Rc, RpSp)-methyl [1-(methoxy)phenylmethyl]phosphonate

dimethyl 1-hydroxy-1-phenylmethylphosphonate