4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethylsulfanyl)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyronitrile

Base Information

Chemical Name:4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethylsulfanyl)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyronitrile
CAS No.:147961-46-4
Molecular Formula:C₃₆H₃₄ClN₃S₂
Molecular Weight:608.271
Hs Code.:

4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethylsulfanyl)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyronitrile

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Chemical Property of 4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethylsulfanyl)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyronitrile

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Technology Process of 4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethylsulfanyl)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyronitrile

There total 17 articles about 4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethylsulfanyl)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3256-88-0
5-phenyl-2-picoline

: 147961-46-4
4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethylsulfanyl)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyronitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 45 percent / N-chlorosuccinimide, benzoyl peroxide / CCl₄ / 5 h / Heating; Irradiation

2: 69 percent / Et₃N / tetrahydrofuran / Ambient temperature

3: 1.) NaH / 1.) DMF, 0 deg C, 5 min, 2.) DMF, 0 deg C, 75 min

4: LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

5: Et₃N / CH₂Cl₂ / 1 h / -78 - 20 °C

6: dimethylformamide; dimethylsulfoxide / 1 h / 125 °C

With N-chloro-succinimide; lithium aluminium tetrahydride; Perbenzoic acid; sodium hydride; triethylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00071a008

Reference yield:

: 146775-28-2
2-chloromethyl-5-phenylpyridine

: 147961-46-4
4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethylsulfanyl)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyronitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 69 percent / Et₃N / tetrahydrofuran / Ambient temperature

2: 1.) NaH / 1.) DMF, 0 deg C, 5 min, 2.) DMF, 0 deg C, 75 min

3: LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

4: Et₃N / CH₂Cl₂ / 1 h / -78 - 20 °C

5: dimethylformamide; dimethylsulfoxide / 1 h / 125 °C

With lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00071a008

Reference yield:

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 147961-46-4
4-[1-(4-Chloro-benzyl)-4-methyl-6-(5-phenyl-pyridin-2-ylmethylsulfanyl)-4,5-dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]-3,3-dimethyl-butyronitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 0 deg C, 5 min, 2.) DMF, 0 deg C, 75 min

2: LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

3: Et₃N / CH₂Cl₂ / 1 h / -78 - 20 °C

4: dimethylformamide; dimethylsulfoxide / 1 h / 125 °C

With lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00071a008