N₁-(4-carboxyphenyl)-N₃-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(2-nitro-phenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea

Base Information

• Chemical Name: N₁-(4-carboxyphenyl)-N₃-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(2-nitro-phenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea
• CAS No.: 1229661-64-6
• Molecular Formula: C₃₂H₃₁N₅O₈S₂
• Molecular Weight: 677.759

Synonyms:

Chemical Property of N₁-(4-carboxyphenyl)-N₃-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(2-nitro-phenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N₁-(4-carboxyphenyl)-N₃-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(2-nitro-phenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea

There total 6 articles about N₁-(4-carboxyphenyl)-N₃-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(2-nitro-phenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H12N2O3S (1229661-70-4) → N1-(4-carboxyphenyl)-N3-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(2-nitro-phenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea (1229661-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / acetone / 37 h / Reflux

2: acetone / 15 h / Reflux

With sodium carbonate; In acetone;

DOI:10.1007/s00044-010-9374-6

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → N1-(4-carboxyphenyl)-N3-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(2-nitro-phenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea (1229661-64-6)

Guidance literature:

Multi-step reaction with 4 steps

1: benzoyl chloride / acetone

2: dicyclohexyl-carbodiimide / tetrahydrofuran; ethanol; water / 2 h / Reflux

3: sodium carbonate / acetone / 37 h / Reflux

4: acetone / 15 h / Reflux

With sodium carbonate; benzoyl chloride; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; water; acetone;

DOI:10.1007/s00044-010-9374-6

Reference yield:

4-thioureidobenzoic acid (7366-56-5) → N1-(4-carboxyphenyl)-N3-{4-[2-hydroxy-3-(5-carbethoxy-6-methyl-2-thio-4-(2-nitro-phenyl)-1,2,3,4-tetrahydropyrimidin-1-yl)propoxy]benzylidene}thiourea (1229661-64-6)

Guidance literature:

Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide / tetrahydrofuran; ethanol; water / 2 h / Reflux

2: sodium carbonate / acetone / 37 h / Reflux

3: acetone / 15 h / Reflux

With sodium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; water; acetone;

DOI:10.1007/s00044-010-9374-6

upstream raw materials:

C₁₅H₁₂N₂O₃S

C₁₈H₁₆N₂O₄S

1,2,3,4-tetrahydro-6-methyl-4-(2-nitrophenyl)-2-thioxo-3-pyrimidinecarboxylic acid ethyl ester

4-thioureidobenzoic acid

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