6-[(S)-3-((S)-2-Chloro-4-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-benzenesulfonyl)-pyrrolidin-1-yl]-pyridine-2-carbonitrile; compound with formic acid

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Chemical Name:6-[(S)-3-((S)-2-Chloro-4-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-benzenesulfonyl)-pyrrolidin-1-yl]-pyridine-2-carbonitrile; compound with formic acid
CAS No.:1374675-14-5
Molecular Formula:CH₂O₂*C₂₃H₂₆ClN₅O₂S
Molecular Weight:518.036
Hs Code.:

6-[(S)-3-((S)-2-Chloro-4-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-benzenesulfonyl)-pyrrolidin-1-yl]-pyridine-2-carbonitrile; compound with formic acid

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Chemical Property of 6-[(S)-3-((S)-2-Chloro-4-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-benzenesulfonyl)-pyrrolidin-1-yl]-pyridine-2-carbonitrile; compound with formic acid

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Technology Process of 6-[(S)-3-((S)-2-Chloro-4-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-benzenesulfonyl)-pyrrolidin-1-yl]-pyridine-2-carbonitrile; compound with formic acid

There total 2 articles about 6-[(S)-3-((S)-2-Chloro-4-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-benzenesulfonyl)-pyrrolidin-1-yl]-pyridine-2-carbonitrile; compound with formic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374675-76-9
(S)-3-(2-Chloro-4-fluoro-phenylsulfanyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1374675-14-5
6-[(S)-3-((S)-2-Chloro-4-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-benzenesulfonyl)-pyrrolidin-1-yl]-pyridine-2-carbonitrile; compound with formic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 25 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 h / 60 °C

3: trifluoroacetic acid / dichloromethane / 16 h

4: triethylamine / acetonitrile / 0.5 h / 160 °C / Microwave oven

With triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane; acetonitrile;

Reference yield:

: 1374675-77-0
(S)-3-(2-Chloro-4-fluoro-benzenesulfonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1374675-14-5
6-[(S)-3-((S)-2-Chloro-4-hexahydro-pyrrolo[1,2-a]pyrazin-2-yl-benzenesulfonyl)-pyrrolidin-1-yl]-pyridine-2-carbonitrile; compound with formic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 h / 60 °C

2: trifluoroacetic acid / dichloromethane / 16 h

3: triethylamine / acetonitrile / 0.5 h / 160 °C / Microwave oven

With triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;