methyl ((S)-1-(2-(2-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

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Chemical Name:methyl ((S)-1-(2-(2-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate
CAS No.:1365541-56-5
Molecular Formula:C₃₇H₄₅BrN₄O₆
Molecular Weight:721.692
Hs Code.:

methyl ((S)-1-(2-(2-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

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Chemical Property of methyl ((S)-1-(2-(2-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

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Technology Process of methyl ((S)-1-(2-(2-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

There total 14 articles about methyl ((S)-1-(2-(2-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₉H₇₃BrN₄O₆Si₂

: 1365541-56-5
methyl ((S)-1-(2-(2-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm201620t

Reference yield:

: 1365541-36-1
(3R,4S)-3-allyl-3-benzyl-4-((tert-butyldimethylsilyl)oxy)-1-((1S,2R)-2-((tert-butyldimethylsilyl)oxy)-2,3-dihydro-1H-inden-1-yl)pyrrolidin-2-one

: 1365541-56-5
methyl ((S)-1-(2-(2-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water / 20 °C

2.1: acetic acid / tetrahydrofuran / 20 °C

2.2: 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With sodium periodate; osmium(VIII) oxide; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; water;
DOI:10.1021/jm201620t

Reference yield:

: (+)-(3R,4R)-3-allyl-4-hydroxydihydrofuran-2(3H)-one

: 1365541-56-5
methyl ((S)-1-(2-(2-((3S,4S)-3-benzyl-4-hydroxy-1-((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl)-2-oxopyrrolidin-3-yl)ethyl)-2-(4-bromobenzyl)hydrazinyl)-3,3-dimethyl-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / -40 - -30 °C

2.1: Dess-Martin periodane / dichloromethane / 1 h / 20 °C

3.1: methanol; sodium tetrahydroborate / tetrahydrofuran / 2 h / 20 °C

4.1: 1-butyl-3-methylimidazolium Tetrafluoroborate / 1,4-dioxane / 0.58 h / 180 °C / Microwave irradiation

5.1: triethylamine / 1,4-dioxane / 0 - 25 °C

6.1: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water / 20 °C

7.1: acetic acid / tetrahydrofuran / 20 °C

7.2: 20 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

With methanol; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; tetrabutyl ammonium fluoride; Dess-Martin periodane; acetic acid; triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; water;
DOI:10.1021/jm201620t