C₂₅H₂₁F₅N₄O₃

Base Information

• Chemical Name: C₂₅H₂₁F₅N₄O₃
• CAS No.: 1379648-87-9
• Molecular Formula: C₂₅H₂₁F₅N₄O₃
• Molecular Weight: 520.459
• Mol file: 1379648-87-9.mol

Synonyms:

Chemical Property of C₂₅H₂₁F₅N₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₁F₅N₄O₃

There total 3 articles about C₂₅H₂₁F₅N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C42H52F5N9O7 → C25H21F5N4O3 (1379648-87-9)

Guidance literature:

With sodium chloride; calcium chloride; aminopeptidase M; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid; In water; dimethyl sulfoxide; at 20 ℃; for 72h; pH=7.5; Enzymatic reaction;

DOI:10.1039/c3cc48132h

Reference yield:

C18H15F5N3O2Pol + 4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → C25H21F5N4O3 (1379648-87-9)

Guidance literature:

C₁₈H₁₅F₅N₃O₂Pol; 4-amino-benzoic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.5h; solid phase reaction;

With chlorotriisopropylsilane; water; trifluoroacetic acid; at 20 ℃; for 2h; solid phase reaction;

DOI:10.1039/c2cc31537h

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → C25H21F5N4O3 (1379648-87-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; chloro-trimethyl-silane / dichloromethane / 3 h / Inert atmosphere; Reflux

1.2: 16 h / 20 °C / Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / 1-methyl-pyrrolidin-2-one / 0.5 h / 20 °C

2.2: 0.17 h / 20 °C

3.1: aminopeptidase M; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid; calcium chloride; sodium chloride / dimethyl sulfoxide; water / 72 h / 20 °C / pH 7.5 / Enzymatic reaction

With chloro-trimethyl-silane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; sodium chloride; calcium chloride; aminopeptidase M; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; water; dimethyl sulfoxide;

DOI:10.1039/c3cc48132h

upstream raw materials:

4-amino-benzoic acid