LYN-1604

Base Information

Chemical Name:LYN-1604
CAS No.:2088939-99-3
Molecular Formula:C₃₃H₄₃Cl₂N₃O₂
Molecular Weight:584.629
Hs Code.:
Mol file:2088939-99-3.mol

Synonyms:

Suppliers and Price of LYN-1604

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
LYN-1604 >98%
250 mg
$ 1100.00

CSNpharm
LYN-1604
10mg
$ 237.00

CSNpharm
LYN-1604
50mg
$ 837.00

CSNpharm
LYN-1604
25mg
$ 493.00

Cayman Chemical
LYN-1604 ≥98%
10mg
$ 488.00

Cayman Chemical
LYN-1604 ≥98%
5mg
$ 260.00

Cayman Chemical
LYN-1604 ≥98%
1mg
$ 65.00

AK Scientific
CID131801113
1mg
$ 187.00

Total 8 raw suppliers

Chemical Property of LYN-1604

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

LYN-1604 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description LYN-1604 is an activator of unc-51-like kinase 1 (ULK1; EC50 = 18.94 nM). It increases Beclin 1, LC3-II, and total LC3 protein levels and reduces levels of p62 in human MDA-MB-231 triple-negative breast cancer (TNBC) cells in a concentration-dependent manner, indicating an increase in autophagy. It also increases the cleavage of the pro-apoptotic protein caspase-3. LYN-1604 decreases the viability of MDA-MB-231 cells in vitro (IC50 = 1.66 μM), an effect that can be reversed by the autophagy inhibitor 3-methyladenine (3-MA; ). LYN-1604 (25, 50, and 100 mg/kg) reduces tumor growth in an MDA-MB-231 mouse xenograft model.

Technology Process of LYN-1604

There total 7 articles about LYN-1604 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 2088939-99-3
LYN-1604

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; at 60 ℃;

Reference yield:

: C₂₈H₃₂Cl₂N₂O₃

: 2088939-99-3
LYN-1604

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 0 °C

2: triethylamine / dichloromethane / 20 °C

3: potassium iodide; triethylamine / acetonitrile

With triethylamine; trifluoroacetic acid; potassium iodide; In dichloromethane; acetonitrile;
DOI:10.1039/C6SC05368H

Reference yield:

: 4252-78-2
2,2',4'-trichloroacetophenone

: 2088939-99-3
LYN-1604

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetonitrile

2: sodium tetrahydroborate / methanol / 20 °C

3: potassium iodide / acetonitrile / Reflux

4: trifluoroacetic acid / dichloromethane / 0 °C

5: triethylamine / dichloromethane / 20 °C

6: potassium iodide; triethylamine / acetonitrile

With sodium tetrahydroborate; potassium carbonate; triethylamine; trifluoroacetic acid; potassium iodide; In methanol; dichloromethane; acetonitrile;
DOI:10.1039/C6SC05368H