C₂₄H₂₂N₂O₄

Base Information

• Chemical Name: C₂₄H₂₂N₂O₄
• CAS No.: 1397815-20-1
• Molecular Formula: C₂₄H₂₂N₂O₄
• Molecular Weight: 402.45
• Mol file: 1397815-20-1.mol

Synonyms:

Chemical Property of C₂₄H₂₂N₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₂N₂O₄

There total 7 articles about C₂₄H₂₂N₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

N-fluorenylmethyloxycarbonyl-4-pyridylalanine-methyl ester (1397697-82-3) → C24H22N2O4 (1397815-20-1) + (S)-N-(9-fluorenylmethoxycarbonyl)-β-(4-pyridyl)alanine (169555-95-7)

Guidance literature:

With ammonium hydroxide; α-chymotrypsine; ammonium acetate; In water; N,N-dimethyl-formamide; at 20 ℃; for 2h; pH=6.9; optical yield given as %ee; Enzymatic reaction;

DOI:10.1007/s00726-010-0829-3

Reference yield:

(4Z)-2-methyl-4((pyridin-4-yl)methylene)oxazol-5(4H)-one (102913-23-5) → C24H22N2O4 (1397815-20-1) + (S)-N-(9-fluorenylmethoxycarbonyl)-β-(4-pyridyl)alanine (169555-95-7)

Guidance literature:

Multi-step reaction with 6 steps

1: water / 100 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 9 h / 20 °C

3: hydrogenchloride; water / 3 h / Reflux

4: sodium hydrogencarbonate / 1,4-dioxane; water / 22 h / 20 °C

5: chloro-trimethyl-silane / 36 h / 40 °C

6: ammonium hydroxide; α-chymotrypsine; ammonium acetate / water; N,N-dimethyl-formamide / 2 h / 20 °C / pH 6.9 / Enzymatic reaction

With hydrogenchloride; ammonium hydroxide; chloro-trimethyl-silane; α-chymotrypsine; palladium 10% on activated carbon; ammonium acetate; water; hydrogen; sodium hydrogencarbonate; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

DOI:10.1007/s00726-010-0829-3

Reference yield:

pyridine-4-carbaldehyde (872-85-5) → C24H22N2O4 (1397815-20-1) + (S)-N-(9-fluorenylmethoxycarbonyl)-β-(4-pyridyl)alanine (169555-95-7)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium acetate; acetic anhydride / 0.02 h / 20 - 100 °C

2: water / 100 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 9 h / 20 °C

4: hydrogenchloride; water / 3 h / Reflux

5: sodium hydrogencarbonate / 1,4-dioxane; water / 22 h / 20 °C

6: chloro-trimethyl-silane / 36 h / 40 °C

7: ammonium hydroxide; α-chymotrypsine; ammonium acetate / water; N,N-dimethyl-formamide / 2 h / 20 °C / pH 6.9 / Enzymatic reaction

With hydrogenchloride; ammonium hydroxide; chloro-trimethyl-silane; α-chymotrypsine; palladium 10% on activated carbon; ammonium acetate; water; hydrogen; sodium acetate; acetic anhydride; sodium hydrogencarbonate; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

DOI:10.1007/s00726-010-0829-3

upstream raw materials:

(4Z)-2-methyl-4((pyridin-4-yl)methylene)oxazol-5(4H)-one

pyridine-4-carbaldehyde

Fmoc-[2-amino-4-(pyridine-4-yl)butanoic acid]

N-fluorenylmethyloxycarbonyl-4-pyridylalanine-methyl ester

Refernces