FK-739 free acid

Base Information

Chemical Name:FK-739 free acid
CAS No.:133052-30-9
Molecular Formula:C24H23N7
Molecular Weight:409.494
Hs Code.:
UNII:57DC310G1M
DSSTox Substance ID:DTXSID6048179
Nikkaji Number:J2.640.046E
Wikidata:Q27261497
ChEMBL ID:CHEMBL158725

Synonyms:FK-739 free acid;133052-30-9;UNII-57DC310G1M;57DC310G1M;CHEMBL158725;3H-Imidazo(4,5-b)pyridine, 2-butyl-3-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-;2-Butyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-3H-imidazo[4,5-b]pyridine;3-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-3H-imidazo[4,5-b]pyridine;UNII-6586Y37C8H;3H-Imidazo[4,5-b]pyridine, 2-butyl-3-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-;FK739;FK 739;2-Butyl-3-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-3H-imidazo(4,5-b)pyridine;SCHEMBL7622112;DTXSID6048179;SCHEMBL12600260;BDBM50049184;AKOS040748356;L004357;Q27261497;2-Butyl-3-[[2'-(1H-tetrazole-5-yl)-4-biphenylyl]methyl]-3H-imidazo[4,5-b]pyridine;2-butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazo[4,5-b]pyridine;2-Butyl-3-[2''-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine

Suppliers and Price of FK-739 free acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of FK-739 free acid

Chemical Property:

XLogP3:4.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:409.20149376
Heavy Atom Count:31
Complexity:552

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCC1=NC2=C(N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)N=CC=C2

Technology Process of FK-739 free acid

There total 5 articles about FK-739 free acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.5%

: 133705-01-8
4'-(2-n-butyl-3H-imidazo<4,5-b>pyridin-3-ylmethyl)biphenyl-2-carbonitrile

: 133052-30-9
2-butyl-3-(2'-(1H-1,2,3,4-tetrazol-5-yl)biphenyl-4-yl)-methyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: With azidotrimethyltin; In toluene; for 118h; Heating;
DOI:10.1016/S0040-4020(01)88351-4

Reference yield:

: 452-58-4
2,3-Diaminopyridine

: 133052-30-9
2-butyl-3-(2'-(1H-1,2,3,4-tetrazol-5-yl)biphenyl-4-yl)-methyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / polyphosphoric acid / 3 h / Heating

2: 56 percent / 1) NaOMe / 1) MeOH, 25 deg C, 2) DMF, 25 deg C, overnight

3: 69.5 percent / Me₃SnN₃ / toluene / 118 h / Heating

With PPA; sodium methylate; azidotrimethyltin; In toluene;
DOI:10.1016/S0040-4020(01)88351-4

Reference yield:

: 68175-10-0
2-n-butyl-imidazo<4,5-b>pyridine

: 133052-30-9
2-butyl-3-(2'-(1H-1,2,3,4-tetrazol-5-yl)biphenyl-4-yl)-methyl-3H-imidazo[4,5-b]pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 56 percent / 1) NaOMe / 1) MeOH, 25 deg C, 2) DMF, 25 deg C, overnight

2: 69.5 percent / Me₃SnN₃ / toluene / 118 h / Heating

With sodium methylate; azidotrimethyltin; In toluene;
DOI:10.1016/S0040-4020(01)88351-4