N-(4-chlorophenyl)-1-methyl-1H-benzo[f ]indazol-3-amine

Base Information

• Chemical Name: N-(4-chlorophenyl)-1-methyl-1H-benzo[f ]indazol-3-amine
• CAS No.: 1373121-87-9
• Molecular Formula: C₁₈H₁₄ClN₃
• Molecular Weight: 307.782
• Mol file: 1373121-87-9.mol

Synonyms:

Chemical Property of N-(4-chlorophenyl)-1-methyl-1H-benzo[f ]indazol-3-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-chlorophenyl)-1-methyl-1H-benzo[f ]indazol-3-amine

There total 2 articles about N-(4-chlorophenyl)-1-methyl-1H-benzo[f ]indazol-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-aniline (106-47-8) → N-(4-chlorophenyl)-1-methyl-1H-benzo[f ]indazol-3-amine (1373121-87-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

2.1: hydrazine / dimethyl sulfoxide / 1 h / 150 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

With sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; hydrazine; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/jm300043c

Reference yield:

2-Amino-3-naphthoic acid (5959-52-4) → N-(4-chlorophenyl)-1-methyl-1H-benzo[f ]indazol-3-amine (1373121-87-9)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sulfuric acid

2.1: tetrafluoroboric acid; sodium nitrite / water / 0.33 h / -15 - 0 °C

2.2: 3 h / Reflux

3.1: water; lithium hydroxide / tetrahydrofuran; methanol / 24 h / 0 - 20 °C

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

5.1: hydrazine / dimethyl sulfoxide / 1 h / 150 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

6.2: 1 h / 20 °C / Inert atmosphere

With tetrafluoroboric acid; sulfuric acid; water; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; hydrazine; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/jm300043c

upstream raw materials:

4-chloro-aniline

2-Amino-3-naphthoic acid