(R)-1-(1-phenyl-1H-pyrazol-4-ylmethyl)-3-(1-thiophen-2-ylcycloheptanecarbonyloxy)-1-azoniabicyclo[2.2.2]octane chloride

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Chemical Name:(R)-1-(1-phenyl-1H-pyrazol-4-ylmethyl)-3-(1-thiophen-2-ylcycloheptanecarbonyloxy)-1-azoniabicyclo[2.2.2]octane chloride
CAS No.:1195983-13-1
Molecular Formula:C₂₉H₃₆N₃O₂S*Cl
Molecular Weight:526.143
Hs Code.:

Synonyms:

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Chemical Property of (R)-1-(1-phenyl-1H-pyrazol-4-ylmethyl)-3-(1-thiophen-2-ylcycloheptanecarbonyloxy)-1-azoniabicyclo[2.2.2]octane chloride

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Technology Process of (R)-1-(1-phenyl-1H-pyrazol-4-ylmethyl)-3-(1-thiophen-2-ylcycloheptanecarbonyloxy)-1-azoniabicyclo[2.2.2]octane chloride

There total 6 articles about (R)-1-(1-phenyl-1H-pyrazol-4-ylmethyl)-3-(1-thiophen-2-ylcycloheptanecarbonyloxy)-1-azoniabicyclo[2.2.2]octane chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35715-71-0
1-phenyl-4-pyrazolylmethyl chloride

: 1026791-35-4
1-thiophen-2-yl-cycloheptanecarboxylic acid (R)-(1-azabicyclo[2.2.2]oct-3-yl) ester

: 1195983-13-1
(R)-1-(1-phenyl-1H-pyrazol-4-ylmethyl)-3-(1-thiophen-2-ylcycloheptanecarbonyloxy)-1-azoniabicyclo[2.2.2]octane chloride

Guidance literature:: In acetonitrile; for 2191.5h;

Reference yield:

: 57382-97-5
ethyl thiophen-2-ylacetate

: 1195983-13-1
(R)-1-(1-phenyl-1H-pyrazol-4-ylmethyl)-3-(1-thiophen-2-ylcycloheptanecarbonyloxy)-1-azoniabicyclo[2.2.2]octane chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: -78 - 20 °C

2.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 20 h / Inert atmosphere; Reflux

3.1: hydrogen / Wilkinson's catalyst / ethanol / 3800.26 Torr

4.1: sodium hydride / toluene / 20 h / Inert atmosphere; Reflux

5.1: acetonitrile / 2191.5 h

With hydrogen; sodium hydride; lithium hexamethyldisilazane; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; Wilkinson's catalyst; In tetrahydrofuran; ethanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1195983-43-7
1-thiophen-2-yl-cyclohept-4-enecarboxylic acid ethyl ester

: 1195983-13-1
(R)-1-(1-phenyl-1H-pyrazol-4-ylmethyl)-3-(1-thiophen-2-ylcycloheptanecarbonyloxy)-1-azoniabicyclo[2.2.2]octane chloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / Wilkinson's catalyst / ethanol / 3800.26 Torr

2: sodium hydride / toluene / 20 h / Inert atmosphere; Reflux

3: acetonitrile / 2191.5 h

With hydrogen; sodium hydride; Wilkinson's catalyst; In ethanol; toluene; acetonitrile;