2-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid

Base Information

Chemical Name:2-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid
CAS No.:1083181-22-9
Molecular Formula:C₉H₁₅NO₄
Molecular Weight:201.222
Hs Code.:
European Community (EC) Number:818-184-3,822-561-8
DSSTox Substance ID:DTXSID90594928

Synonyms:1083181-22-9;2-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid;2-(tert-butoxycarbonylamino)cyclopropanecarboxylic acid;2-(BOC-AMINO)CYCLOPROPANECARBOXYLIC ACID;2-{[(tert-butoxy)carbonyl]amino}cyclopropane-1-carboxylic acid;2-[(2-methylpropan-2-yl)oxycarbonylamino]cyclopropane-1-carboxylic acid;Cyclopropanecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-;MFCD11558998;2-Bocamino-cyclopropanecarboxylic acid;2-[[(1,1-dimethylethoxy)carbonyl]amino]cyclopropanecarboxylic acid;trans-2-tert-Butoxycarbonylamino-cyclopropanecarboxylic acid;1810070-30-4;956440-43-0;cis-2-tert-Butoxycarbonylamino-cyclopropanecarboxylic acid;(1R,2R)-2-((TERT-BUTOXYCARBONYL)AMINO)CYCLOPROPANECARBOXYLIC ACID;SCHEMBL478960;2-tert-Butoxycarbonylamino-cyclopropanecarboxylic acid;(1R,2S)-2-((tert-butoxycarbonyl)amino)cyclopropane-1-carboxylic acid;SCHEMBL20883075;DTXSID90594928;Cyclopropanecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (1R,2R)-;Cyclopropanecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (1R,2S)-;Cyclopropanecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (1S,2R)-;Cyclopropanecarboxylic acid, 2-[[(1,1-dimethylethoxy)carbonyl]amino]-, (1S,2S)-;rel-(1R,2R)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclopropanecarboxylic acid;2-[[(1,1-Dimethylethoxy)carbonyl]amino]-cyclopropanecarboxylic acid;AKOS016344432;AB86084;SB30523;SB31793;SB34464;BS-50370;SY172618;CS-0021633;EN300-29386;2-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylicacid;F2147-1407;(1R,2R)-2-(tert-Butoxycarbonyl)cyclopropanecarboxylic acid;2-[(TERT-BUTOXYCARBONYL)AMINO]CYCLOPROPANE-1-CARBOXYLIC ACID

Suppliers and Price of 2-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 10 raw suppliers

Chemical Property of 2-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:201.10010796
Heavy Atom Count:14
Complexity:256

Purity/Quality:: 99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1CC1C(=O)O

Technology Process of 2-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid

There total 3 articles about 2-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.52%

: 629657-16-5
(1S,2S)-2-[bis(tert-butoxycarbonyl)amino]cyclopropane-1-carboxylic acid

: 1083181-22-9,1810070-30-4
(trans)-2-[(tert-butoxy)carbonyl]aminocyclopropane-1-carboxylic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1083181-22-9,1810070-30-4
(trans)-2-[(tert-butoxy)carbonyl]aminocyclopropane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / acetonitrile / 18 h / 25 °C

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 18 °C

3: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With dmap; lithium hydroxide monohydrate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; acetonitrile;

Reference yield:

: C₁₅H₂₅NO₆

: 1083181-22-9,1810070-30-4
(trans)-2-[(tert-butoxy)carbonyl]aminocyclopropane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide monohydrate / tetrahydrofuran; water / 12 h / 18 °C

2: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

With lithium hydroxide monohydrate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;