(Rp)-methylphenyl-m-xylylphosphine borane

Base Information

• Chemical Name: (Rp)-methylphenyl-m-xylylphosphine borane
• CAS No.: 1258559-80-6
• Molecular Formula: C₁₅H₂₀BP
• Molecular Weight: 242.109
• Mol file: 1258559-80-6.mol

Synonyms:

Chemical Property of (Rp)-methylphenyl-m-xylylphosphine borane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Rp)-methylphenyl-m-xylylphosphine borane

There total 1 articles about (Rp)-methylphenyl-m-xylylphosphine borane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(Rp)-(-)-N-methyl-[(1R,2S)(2-hydroxy-1-phenyl)ethyl]-aminophenyl-m-xylyl phosphine borate + methyllithium (917-54-4) → (Rp)-methylphenyl-m-xylylphosphine borane (1258517-45-1,1258559-80-6)

Guidance literature:

With HCl; H₂O; In toluene; byproducts: ephedrine hydrochloride; (Ar); 0.38 M HCl in toluene was added to borane, stirred for 1 h at r.t., filtered, HCl was removed in vac., cooled to -78°C, 0.87 M MeLiwas added, warmed to r.t. for 1 h, water was added; aq. layer was extd. with CH2Cl2, extracts were dried over MgSO4, concd.,column chromy. (silica, toluene/petroleum ether, 7:3), crystd. from iPr OH/hexane, elem anal.;

DOI:10.1039/c0dt00542h

Reference yield: 70.0%

(Rp)-methylphenyl-m-xylylphosphine borane (1258517-45-1,1258559-80-6) + (S)-(chloro)(m-xylyl)phosphine/borane complex (1256150-26-1) → (R,R)-(+)-bis(phenyl-m-xylylphosphino borane)methane (1258517-47-3,1258517-49-5)

Guidance literature:

With n-C₄H₉Li; H₂O; In tetrahydrofuran; hexane; toluene; (Ar); soln. of borane in THF was treated at 0°C with 1.6 M BuLi in hexane, stirrd for 30 min, warmed to r.t., stirred for 90 min, cooled to -78°C, soln. of chlorophosphine borane in toluene was added, warmet to r.t overnight, hydrolised; aq. layer was exted. with CH2Cl2, dried over MgSO4, concd., column cjhromy. (silica, toluene), crystd. from CH2Cl2/heptane, elem. anal.;

DOI:10.1039/c0dt00542h

Reference yield:

(S)-(+)-methylphenyl-m-xylylphosphine borane (1258559-80-6) + (R)-chlorophenyl-m-xylylphosphine borane (1256150-26-1) → (S,S)-(-)-bis(phenyl-m-xylylphosphino borane)methane (1258517-49-5)

Guidance literature:

In not given;

DOI:10.1039/c0dt00542h

upstream raw materials:

methyllithium

Downstream raw materials:

(R,R)-(+)-bis(phenyl-m-xylylphosphino borane)methane

(S,S)-(-)-bis(phenyl-m-xylylphosphino borane)methane