Technology Process of (8-chloronaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone
There total 3 articles about (8-chloronaphthalen-1-yl)(1-pentyl-1H-indol-3-yl)methanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-pentyl-1H-indole;
With
dimethylaluminum chloride;
In
hexane; dichloromethane;
at 0 ℃;
for 1h;
Inert atmosphere;
C11H6Cl2O;
In
hexane; dichloromethane;
at 0 - 20 ℃;
for 6h;
Inert atmosphere;
DOI:10.1016/j.bmc.2012.01.038
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: chlorine; acetic acid / dichloromethane / Cooling with ice
2.1: thionyl chloride / 2 h / Inert atmosphere; Reflux
3.1: dimethylaluminum chloride / hexane; dichloromethane / 1 h / 0 °C / Inert atmosphere
3.2: 6 h / 0 - 20 °C / Inert atmosphere
With
thionyl chloride; dimethylaluminum chloride; chlorine; acetic acid;
In
hexane; dichloromethane;
3.1: Friedel-Crafts reaction / 3.2: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2012.01.038
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: thionyl chloride / 2 h / Inert atmosphere; Reflux
2.1: dimethylaluminum chloride / hexane; dichloromethane / 1 h / 0 °C / Inert atmosphere
2.2: 6 h / 0 - 20 °C / Inert atmosphere
With
thionyl chloride; dimethylaluminum chloride;
In
hexane; dichloromethane;
2.1: Friedel-Crafts reaction / 2.2: Friedel-Crafts reaction;
DOI:10.1016/j.bmc.2012.01.038
