Technology Process of (2R)-1-(1,3-benzothiazol-2-ylsulfanyl)propan-2-yl (2S)-methoxy(phenyl)ethanoate
There total 5 articles about (2R)-1-(1,3-benzothiazol-2-ylsulfanyl)propan-2-yl (2S)-methoxy(phenyl)ethanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium hydroxide / ethanol / 0.25 h / 80 °C / Inert atmosphere
1.2: 20 h / 20 °C / Inert atmosphere
2.1: sodium tetrahydroborate / methanol / 2 h / 0 - 5 °C / Inert atmosphere
3.1: amano PS (native lipase from B. cepacia earlier Pseudomonas cepacia) / toluene / 306 h / 32 °C / Resolution of racemate; Enzymatic reaction
4.1: dicyclohexyl-carbodiimide; dmap / dichloromethane
With
dmap; sodium tetrahydroborate; amano PS (native lipase from B. cepacia earlier Pseudomonas cepacia); dicyclohexyl-carbodiimide; potassium hydroxide;
In
methanol; ethanol; dichloromethane; toluene;
DOI:10.1016/j.tet.2013.04.014
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium tetrahydroborate / methanol / 2 h / 0 - 5 °C / Inert atmosphere
2: amano PS (native lipase from B. cepacia earlier Pseudomonas cepacia) / toluene / 306 h / 32 °C / Resolution of racemate; Enzymatic reaction
3: dicyclohexyl-carbodiimide; dmap / dichloromethane
With
dmap; sodium tetrahydroborate; amano PS (native lipase from B. cepacia earlier Pseudomonas cepacia); dicyclohexyl-carbodiimide;
In
methanol; dichloromethane; toluene;
DOI:10.1016/j.tet.2013.04.014
