C₁₆H₁₈F₃N₃O

Base Information

• Chemical Name: C₁₆H₁₈F₃N₃O
• CAS No.: 1261167-37-6
• Molecular Formula: C₁₆H₁₈F₃N₃O
• Molecular Weight: 325.334
• Mol file: 1261167-37-6.mol

Synonyms:

Chemical Property of C₁₆H₁₈F₃N₃O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₁₈F₃N₃O

There total 2 articles about C₁₆H₁₈F₃N₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C16H16F3N3O3 → C16H18F3N3O (1261167-37-6)

Guidance literature:

With hydrogenchloride; iron(III) chloride; water; zinc; at 100 ℃; for 1h;

DOI:10.1021/co100040z

Reference yield:

1-fluoro-2-nitro-4-trifluoromethyl-benzene (367-86-2) + 2-cyano-N-cyclohexylacetamide (15029-38-6) → C16H18F3N3O (1261167-37-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h

1.2: 1 h / 20 °C

2.1: hydrogenchloride; iron(III) chloride; water; zinc / 1 h / 100 °C

With hydrogenchloride; iron(III) chloride; water; sodium hydride; zinc; In N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/co100040z

upstream raw materials:

1-fluoro-2-nitro-4-trifluoromethyl-benzene

2-cyano-N-cyclohexylacetamide

Refernces