(3-{[(S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-1-(3,4-dichloro-benzyl)-2-oxo-imidazolidine-4-carbonyl]-amino}-2-hydroxy-hexanoylamino)-acetic acid allyl ester

Base Information

Chemical Name:(3-{[(S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-1-(3,4-dichloro-benzyl)-2-oxo-imidazolidine-4-carbonyl]-amino}-2-hydroxy-hexanoylamino)-acetic acid allyl ester
CAS No.:811803-61-9
Molecular Formula:C₃₂H₄₅Cl₂N₅O₉
Molecular Weight:714.643
Hs Code.:

(3-{[(S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-1-(3,4-dichloro-benzyl)-2-oxo-imidazolidine-4-carbonyl]-amino}-2-hydroxy-hexanoylamino)-acetic acid allyl ester

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Chemical Property of (3-{[(S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-1-(3,4-dichloro-benzyl)-2-oxo-imidazolidine-4-carbonyl]-amino}-2-hydroxy-hexanoylamino)-acetic acid allyl ester

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Technology Process of (3-{[(S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-1-(3,4-dichloro-benzyl)-2-oxo-imidazolidine-4-carbonyl]-amino}-2-hydroxy-hexanoylamino)-acetic acid allyl ester

There total 5 articles about (3-{[(S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-1-(3,4-dichloro-benzyl)-2-oxo-imidazolidine-4-carbonyl]-amino}-2-hydroxy-hexanoylamino)-acetic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: (3-amino-2-hydroxy-hexanoylamino)-acetic acid allyl ester; hydrochloride

: 811803-59-5
(S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-1-(3,4-dichloro-benzyl)-2-oxo-imidazolidine-4-carboxylic acid

: 811803-61-9
(3-{[(S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-1-(3,4-dichloro-benzyl)-2-oxo-imidazolidine-4-carbonyl]-amino}-2-hydroxy-hexanoylamino)-acetic acid allyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
DOI:10.1016/j.bmcl.2004.09.058

Reference yield:

: 3392-12-9
Boc-Val-ONSu

: 811803-61-9
(3-{[(S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-1-(3,4-dichloro-benzyl)-2-oxo-imidazolidine-4-carbonyl]-amino}-2-hydroxy-hexanoylamino)-acetic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: KO-tBu / tetrahydrofuran / -40 °C

1.2: tetrahydrofuran / -40 °C

2.1: 100 percent / aq. LiOH / methanol; tetrahydrofuran

3.1: 98 percent / EDCI; HOBt; NMM

With 4-methyl-morpholine; lithium hydroxide; potassium tert-butylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2004.09.058

Reference yield:

: 18880-04-1
3,4-dichlorobenzyl bromide

: 811803-61-9
(3-{[(S)-3-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyryl)-1-(3,4-dichloro-benzyl)-2-oxo-imidazolidine-4-carbonyl]-amino}-2-hydroxy-hexanoylamino)-acetic acid allyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: K₂CO₃; TBAI / 1,2-dimethoxy-ethane

2.1: HBr; AcOH

3.1: KO-tBu / tetrahydrofuran / -40 °C

3.2: tetrahydrofuran / -40 °C

4.1: 100 percent / aq. LiOH / methanol; tetrahydrofuran

5.1: 98 percent / EDCI; HOBt; NMM

With 4-methyl-morpholine; lithium hydroxide; potassium tert-butylate; hydrogen bromide; tetra-(n-butyl)ammonium iodide; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane;
DOI:10.1016/j.bmcl.2004.09.058