[2-({2-[6-(3-sec-butylcarbamoyl-5-nitro-phenyl)-3-isopropylamino-2-oxo-2H-pyrazin-1-yl]-acetylamino}-methyl)-5-carbamimidoyl-benzoylamino]-acetic acid

Base Information

Chemical Name:[2-({2-[6-(3-sec-butylcarbamoyl-5-nitro-phenyl)-3-isopropylamino-2-oxo-2H-pyrazin-1-yl]-acetylamino}-methyl)-5-carbamimidoyl-benzoylamino]-acetic acid
CAS No.:861882-93-1
Molecular Formula:C₃₁H₃₇N₉O₈
Molecular Weight:663.69
Hs Code.:

[2-({2-[6-(3-<i>sec</i>-butylcarbamoyl-5-nitro-phenyl)-3-isopropylamino-2-oxo-2<i>H</i>-pyrazin-1-yl]-acetylamino}-methyl)-5-carbamimidoyl-benzoylamino]-acetic acid

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Chemical Property of [2-({2-[6-(3-sec-butylcarbamoyl-5-nitro-phenyl)-3-isopropylamino-2-oxo-2H-pyrazin-1-yl]-acetylamino}-methyl)-5-carbamimidoyl-benzoylamino]-acetic acid

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Technology Process of [2-({2-[6-(3-sec-butylcarbamoyl-5-nitro-phenyl)-3-isopropylamino-2-oxo-2H-pyrazin-1-yl]-acetylamino}-methyl)-5-carbamimidoyl-benzoylamino]-acetic acid

There total 10 articles about [2-({2-[6-(3-sec-butylcarbamoyl-5-nitro-phenyl)-3-isopropylamino-2-oxo-2H-pyrazin-1-yl]-acetylamino}-methyl)-5-carbamimidoyl-benzoylamino]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 861882-69-1
t-butyl 2,5-dibromobenzoate

: 861882-93-1
[2-({2-[6-(3-sec-butylcarbamoyl-5-nitro-phenyl)-3-isopropylamino-2-oxo-2H-pyrazin-1-yl]-acetylamino}-methyl)-5-carbamimidoyl-benzoylamino]-acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1: 80 percent / Pd(PPh₃)4 / dimethylformamide

2: 91 percent / NH₂OH*HCl; DIEA

3: 80 percent / H₂; acetic acid / Pd/C

4: 100 percent / TFA

5: DIC

6: TFA

7: HBTU; DIEA / dimethylformamide / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; dacarbazine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.04.037

Reference yield:

: 861882-70-4
2,5-dicyano-benzoic acid tert-butyl ester

: 861882-93-1
[2-({2-[6-(3-sec-butylcarbamoyl-5-nitro-phenyl)-3-isopropylamino-2-oxo-2H-pyrazin-1-yl]-acetylamino}-methyl)-5-carbamimidoyl-benzoylamino]-acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 91 percent / NH₂OH*HCl; DIEA

2: 80 percent / H₂; acetic acid / Pd/C

3: 100 percent / TFA

4: DIC

5: TFA

6: HBTU; DIEA / dimethylformamide / 20 °C

With hydroxylamine hydrochloride; hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; dacarbazine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.04.037

Reference yield:

: 861882-71-5
2-cyano-5-(N-hydroxycarbamimidoyl)-benzoic acid tert-butyl ester

: 861882-93-1
[2-({2-[6-(3-sec-butylcarbamoyl-5-nitro-phenyl)-3-isopropylamino-2-oxo-2H-pyrazin-1-yl]-acetylamino}-methyl)-5-carbamimidoyl-benzoylamino]-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / H₂; acetic acid / Pd/C

2: 100 percent / TFA

3: DIC

4: TFA

5: HBTU; DIEA / dimethylformamide / 20 °C

With hydrogen; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; dacarbazine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium on activated charcoal; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.04.037