2-(p-Tolyl)-2,3-dihydroquinazolin-4(1H)-one

Base Information

• Chemical Name: 2-(p-Tolyl)-2,3-dihydroquinazolin-4(1H)-one
• CAS No.: 13324-79-3
• Molecular Formula: C15H14N2O
• Molecular Weight: 238.289
• European Community (EC) Number: 653-901-1
• DSSTox Substance ID: DTXSID501227008
• Nikkaji Number: J1.854.970K
• ChEMBL ID: CHEMBL3594134
• Mol file: 13324-79-3.mol

Synonyms:13324-79-3;2-(p-Tolyl)-2,3-dihydroquinazolin-4(1H)-one;2-(4-methylphenyl)-1,2,3,4-tetrahydroquinazolin-4-one;Oprea1_753364;1,2-DIHYDRO-2-(P-TOLYL)-4(3H)-QUINAZOLINONE;CHEMBL3594134;BDBM150780;DTXSID501227008;STL168352;AKOS001305191;2,3-dihydro-2-p-tolylquinazolin-4(1h)-one;EN300-26478311;2,3-Dihydro-2-(4-methylphenyl)-4(1H)-quinazolinone;2-(4-methylphenyl)-2,3-dihydroquinazolin-4(1H)-one;Z48978260;1,2-Dihydro-2-(4-methylphenyl)quinazoline-4(3H)-one;2-(4-Methylphenyl)-2,3-dihydroquinazolin-4(1H)-one (1c)

Chemical Property of 2-(p-Tolyl)-2,3-dihydroquinazolin-4(1H)-one

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 238.110613074
• Heavy Atom Count: 18
• Complexity: 310

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2NC3=CC=CC=C3C(=O)N2

Technology Process of 2-(p-Tolyl)-2,3-dihydroquinazolin-4(1H)-one

There total 13 articles about 2-(p-Tolyl)-2,3-dihydroquinazolin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methyl-benzaldehyde (104-87-0) + anthranilic acid amide (28144-70-9,88-68-6) → 2,3-dihydro-2-(4-methylphenyl)quinazolin-4(1H)-one (13324-79-3)

Guidance literature:

With copper(II) Schiff base complex supported on Fe₃O₄; In ethanol; for 1.75h; Reflux; Green chemistry;

DOI:10.1002/aoc.3354

Reference yield: 98.0%

isatoic anhydride (118-48-9) + 4-methyl-benzaldehyde (104-87-0) → 2,3-dihydro-2-(4-methylphenyl)quinazolin-4(1H)-one (13324-79-3)

Guidance literature:

With ammonium acetate; iodine; at 110 ℃; for 0.416667h;

DOI:10.1080/00397910802178427

Reference yield: 96.0%

4-methyl-benzaldehyde (104-87-0) + homophthalic anhydride (703-59-3) → 2,3-dihydro-2-(4-methylphenyl)quinazolin-4(1H)-one (13324-79-3)

Guidance literature:

With ammonium acetate; at 70 ℃; for 0.166667h; Neat (no solvent);

DOI:10.1002/jhet.592

upstream raw materials:

2-nitrobenzamide

4-methyl-benzaldehyde

isatoic anhydride

anthranilic acid amide

Downstream raw materials:

2-(4-methylphenyl)-4(3H)-quinazolinone

C₁₆H₁₃N₅

2-p-tolylquinazoline-4(3H)-thione

C₁₅H₁₄N₄