(4S,8S,9S,10R,13R,14S,17R)-3-Formyl-4,13,14-trimethyl-17-((R)-1,4,5-trimethyl-6-trityloxy-hexyl)-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthrene-4-carboxylic acid methyl ester

Base Information

• Chemical Name: (4S,8S,9S,10R,13R,14S,17R)-3-Formyl-4,13,14-trimethyl-17-((R)-1,4,5-trimethyl-6-trityloxy-hexyl)-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthrene-4-carboxylic acid methyl ester
• CAS No.: 82526-91-8
• Molecular Formula: C₅₂H₆₈O₄
• Molecular Weight: 757.11

Synonyms:

Chemical Property of (4S,8S,9S,10R,13R,14S,17R)-3-Formyl-4,13,14-trimethyl-17-((R)-1,4,5-trimethyl-6-trityloxy-hexyl)-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthrene-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,8S,9S,10R,13R,14S,17R)-3-Formyl-4,13,14-trimethyl-17-((R)-1,4,5-trimethyl-6-trityloxy-hexyl)-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthrene-4-carboxylic acid methyl ester

There total 9 articles about (4S,8S,9S,10R,13R,14S,17R)-3-Formyl-4,13,14-trimethyl-17-((R)-1,4,5-trimethyl-6-trityloxy-hexyl)-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthrene-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.7%

(4S,8S,9S,10R,13R,14S,17R)-3-Hydroxymethyl-4,13,14-trimethyl-17-((R)-1,4,5-trimethyl-6-trityloxy-hexyl)-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthrene-4-carboxylic acid methyl ester (82526-90-7,82536-65-0) → (4S,8S,9S,10R,13R,14S,17R)-3-Formyl-4,13,14-trimethyl-17-((R)-1,4,5-trimethyl-6-trityloxy-hexyl)-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthrene-4-carboxylic acid methyl ester (82526-91-8,82536-66-1)

Guidance literature:

With pyridine; chromium(VI) oxide; In dichloromethane; at 25 ℃; for 0.5h;

DOI:10.1016/0040-4020(82)80177-4

Reference yield:

24-methyl-9,19-cyclolanostane-25-en-3β-ol (108864-87-5) → (4S,8S,9S,10R,13R,14S,17R)-3-Formyl-4,13,14-trimethyl-17-((R)-1,4,5-trimethyl-6-trityloxy-hexyl)-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthrene-4-carboxylic acid methyl ester (82526-91-8,82536-66-1)

Guidance literature:

Multi-step reaction with 9 steps

1: 1.) diborane, 2.) 30percent H₂O₂, NaOH / 1.) THF, 10-15 deg C, then 25 deg C, 4 h, 2.) 0 deg C, water, then 25 deg C, 2 h

2: 89.8 percent / pyridine / benzene / 19 h / Heating

3: 78.6 percent / CrO₃ / pyridine; CH₂Cl₂ / 4 h / 25 °C

4: 79.4 percent / t-BuOK / tetrahydrofuran / 1 h / 30 °C

5: 1.) 9-BBN, NaOH, 30percent, H₂O₂ / 1.) THF, reflux, 3 h, 2.) 0 deg C, water, then 27 deg C, 4 h

6: 1.) Pb(OAc)4, I₂, 2.) CrO₃ / 1.) cyclohexane, irradiated, reflux, 3 h, 2.) pyridine, CH₂Cl₂, 1 h

7: KOH / H₂O; tetrahydrofuran / Heating

8: diethyl ether

9: 87.7 percent / CrO₃, pyridine / CH₂Cl₂ / 0.5 h / 25 °C

With pyridine; chromium(VI) oxide; lead(IV) acetate; potassium hydroxide; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; potassium tert-butylate; dihydrogen peroxide; iodine; diborane; In tetrahydrofuran; pyridine; diethyl ether; dichloromethane; water; benzene;

DOI:10.1016/0040-4020(82)80177-4

Reference yield:

26-hydroxycyclolaudan-3β-ol (77031-47-1,82570-38-5,82570-39-6) → (4S,8S,9S,10R,13R,14S,17R)-3-Formyl-4,13,14-trimethyl-17-((R)-1,4,5-trimethyl-6-trityloxy-hexyl)-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthrene-4-carboxylic acid methyl ester (82526-91-8,82536-66-1)

Guidance literature:

Multi-step reaction with 8 steps

1: 89.8 percent / pyridine / benzene / 19 h / Heating

2: 78.6 percent / CrO₃ / pyridine; CH₂Cl₂ / 4 h / 25 °C

3: 79.4 percent / t-BuOK / tetrahydrofuran / 1 h / 30 °C

4: 1.) 9-BBN, NaOH, 30percent, H₂O₂ / 1.) THF, reflux, 3 h, 2.) 0 deg C, water, then 27 deg C, 4 h

5: 1.) Pb(OAc)4, I₂, 2.) CrO₃ / 1.) cyclohexane, irradiated, reflux, 3 h, 2.) pyridine, CH₂Cl₂, 1 h

6: KOH / H₂O; tetrahydrofuran / Heating

7: diethyl ether

8: 87.7 percent / CrO₃, pyridine / CH₂Cl₂ / 0.5 h / 25 °C

With pyridine; chromium(VI) oxide; lead(IV) acetate; potassium hydroxide; sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; potassium tert-butylate; dihydrogen peroxide; iodine; In tetrahydrofuran; pyridine; diethyl ether; dichloromethane; water; benzene;

DOI:10.1016/0040-4020(82)80177-4

upstream raw materials:

(4S,8S,9S,10R,13R,14S,17R)-3-Hydroxymethyl-4,13,14-trimethyl-17-((R)-1,4,5-trimethyl-6-trityloxy-hexyl)-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthrene-4-carboxylic acid methyl ester

24-methyl-9,19-cyclolanostane-25-en-3β-ol

26-hydroxycyclolaudan-3β-ol

26-trityloxycyclolaudan-3β-ol

Downstream raw materials:

methyl 3-oxo-trityloxycycolaudan-29-oate

(4S,8S,9S,10R,13R,14S,17R)-4,13,14-Trimethyl-3-[1-piperidin-1-yl-meth-(Z)-ylidene]-17-((R)-1,4,5-trimethyl-6-trityloxy-hexyl)-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthrene-4-carboxylic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 82526-91-8 (4S,8S,9S,10R,13R,14S,17R)-3-Formyl-4,13,14-trimethyl-17-((R)-1,4,5-trimethyl-6-trityloxy-hexyl)-tetradecahydro-cyclopropa[9,10]cyclopenta[a]phenanthrene-4-carboxylic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send