2-Amino-3-(4-difluoromethoxy-phenyl)-propionic acid

Base Information

Chemical Name:2-Amino-3-(4-difluoromethoxy-phenyl)-propionic acid
CAS No.:126300-89-8
Molecular Formula:C₁₀H₁₁F₂NO₃
Molecular Weight:231.199
Hs Code.:
ChEMBL ID:CHEMBL1561937
DSSTox Substance ID:DTXSID601311094

Synonyms:2-amino-3-[4-(difluoromethoxy)phenyl]propanoic Acid;126300-89-8;2-Amino-3-(4-(difluoromethoxy)phenyl)propanoic acid;O-(Difluoromethyl)tyrosine;MLS000757655;CHEMBL1561937;SCHEMBL13620420;DTXSID601311094;HMS2751O10;AKOS000184268;AKOS017268671;SMR000371954;CS-0344498;EN300-88025;2-amino-3-[4-(difluoromethoxy)phenyl]propanoicAcid;A1-14730;Z56767337

Suppliers and Price of 2-Amino-3-(4-difluoromethoxy-phenyl)-propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 2-Amino-3-(4-difluoromethoxy-phenyl)-propionic acid

Chemical Property:

XLogP3:-0.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:231.07069954
Heavy Atom Count:16
Complexity:230

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1CC(C(=O)O)N)OC(F)F

Technology Process of 2-Amino-3-(4-difluoromethoxy-phenyl)-propionic acid

There total 2 articles about 2-Amino-3-(4-difluoromethoxy-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1583-83-1
4-methyl-α,α-difluoroanisole

: 126300-89-8
2-Amino-3-(4-difluoromethoxy-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / Br₂ / CCl₄ / 0.5 h / Heating; Irradiation

2: 78 percent / NaOC₂H₅ / 3.5 h / Heating

3: 1.) NaCl, H₂O, 2.) 10percent aq. KOH / 1.) DMSO, 210 deg C, 4 h, 2.) dioxane, 70 deg C, 2.5 h

With potassium hydroxide; water; bromine; sodium ethanolate; sodium chloride; In tetrachloromethane;

Reference yield:

: 3447-53-8
4-(difluoromethoxy)benzyl bromide

: 126300-89-8
2-Amino-3-(4-difluoromethoxy-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / NaOC₂H₅ / 3.5 h / Heating

2: 1.) NaCl, H₂O, 2.) 10percent aq. KOH / 1.) DMSO, 210 deg C, 4 h, 2.) dioxane, 70 deg C, 2.5 h

With potassium hydroxide; water; sodium ethanolate; sodium chloride;