(S)-1-(2-{[(2-{1-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-butyrylamino]-3-carbamoyl-propyl}-thiazole-4-carbonyl)-amino]-methyl}-thiazole-4-carbonyl)-pyrrolidine-2-carboxylic acid 2,4,5-trichloro-phenyl ester; compound with trifluoro-acetic acid

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Chemical Name:(S)-1-(2-{[(2-{1-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-butyrylamino]-3-carbamoyl-propyl}-thiazole-4-carbonyl)-amino]-methyl}-thiazole-4-carbonyl)-pyrrolidine-2-carboxylic acid 2,4,5-trichloro-phenyl ester; compound with trifluoro-acetic acid
CAS No.:104619-65-0
Molecular Formula:C₂HF₃O₂*C₃₅H₄₃Cl₃N₈O₇S₂
Molecular Weight:972.291
Hs Code.:

(S)-1-(2-{[(2-{1-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-butyrylamino]-3-carbamoyl-propyl}-thiazole-4-carbonyl)-amino]-methyl}-thiazole-4-carbonyl)-pyrrolidine-2-carboxylic acid 2,4,5-trichloro-phenyl ester; compound with trifluoro-acetic acid

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Chemical Property of (S)-1-(2-{[(2-{1-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-butyrylamino]-3-carbamoyl-propyl}-thiazole-4-carbonyl)-amino]-methyl}-thiazole-4-carbonyl)-pyrrolidine-2-carboxylic acid 2,4,5-trichloro-phenyl ester; compound with trifluoro-acetic acid

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Technology Process of (S)-1-(2-{[(2-{1-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-butyrylamino]-3-carbamoyl-propyl}-thiazole-4-carbonyl)-amino]-methyl}-thiazole-4-carbonyl)-pyrrolidine-2-carboxylic acid 2,4,5-trichloro-phenyl ester; compound with trifluoro-acetic acid

There total 5 articles about (S)-1-(2-{[(2-{1-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-butyrylamino]-3-carbamoyl-propyl}-thiazole-4-carbonyl)-amino]-methyl}-thiazole-4-carbonyl)-pyrrolidine-2-carboxylic acid 2,4,5-trichloro-phenyl ester; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3392-09-4
Boc-Leu-ONSu

: 104619-65-0,104712-90-5
(S)-1-(2-{[(2-{1-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-butyrylamino]-3-carbamoyl-propyl}-thiazole-4-carbonyl)-amino]-methyl}-thiazole-4-carbonyl)-pyrrolidine-2-carboxylic acid 2,4,5-trichloro-phenyl ester; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 16 h / Ambient temperature

2: 86 percent / 0.1 N NaOH / dioxane / 2 h / Ambient temperature

3: 68 percent / dicyclohexylcarbodiimide / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

4: CH₂Cl₂ / 0 °C

With 4-methyl-morpholine; sodium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00374a017

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 104619-65-0,104712-90-5
(S)-1-(2-{[(2-{1-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-butyrylamino]-3-carbamoyl-propyl}-thiazole-4-carbonyl)-amino]-methyl}-thiazole-4-carbonyl)-pyrrolidine-2-carboxylic acid 2,4,5-trichloro-phenyl ester; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, 3 h

2: N-methylmorpholine / tetrahydrofuran; dimethylformamide / 16 h / Ambient temperature

3: 86 percent / 0.1 N NaOH / dioxane / 2 h / Ambient temperature

4: 68 percent / dicyclohexylcarbodiimide / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

5: CH₂Cl₂ / 0 °C

With 4-methyl-morpholine; sodium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00374a017

Reference yield:

: 104619-62-7,104712-87-0
Boc-L-Leu-L-Val-(R,S)-(gln)Thz-(gly)Thz-L-Pro

: 104619-65-0,104712-90-5
(S)-1-(2-{[(2-{1-[(S)-2-((S)-2-Amino-4-methyl-pentanoylamino)-3-methyl-butyrylamino]-3-carbamoyl-propyl}-thiazole-4-carbonyl)-amino]-methyl}-thiazole-4-carbonyl)-pyrrolidine-2-carboxylic acid 2,4,5-trichloro-phenyl ester; compound with trifluoro-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / dicyclohexylcarbodiimide / dimethylformamide / 1.) 0 deg C, 1 h, 2.) RT, 16 h

2: CH₂Cl₂ / 0 °C

With dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00374a017