2-[5-[1-[5-Carboxy-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-1-cyano-meth-(E)-ylidene]-4,4-dimethyl-pyrrolidin-(2E)-ylidene]-malonic acid monobenzyl ester

Base Information

Chemical Name:2-[5-[1-[5-Carboxy-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-1-cyano-meth-(E)-ylidene]-4,4-dimethyl-pyrrolidin-(2E)-ylidene]-malonic acid monobenzyl ester
CAS No.:145045-98-3
Molecular Formula:C₃₀H₃₁N₃O₁₀
Molecular Weight:593.59
Hs Code.:

2-[5-[1-[5-Carboxy-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-1-cyano-meth-(E)-ylidene]-4,4-dimethyl-pyrrolidin-(2E)-ylidene]-malonic acid monobenzyl ester

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Chemical Property of 2-[5-[1-[5-Carboxy-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-1-cyano-meth-(E)-ylidene]-4,4-dimethyl-pyrrolidin-(2E)-ylidene]-malonic acid monobenzyl ester

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Technology Process of 2-[5-[1-[5-Carboxy-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-1-cyano-meth-(E)-ylidene]-4,4-dimethyl-pyrrolidin-(2E)-ylidene]-malonic acid monobenzyl ester

There total 4 articles about 2-[5-[1-[5-Carboxy-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-1-cyano-meth-(E)-ylidene]-4,4-dimethyl-pyrrolidin-(2E)-ylidene]-malonic acid monobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145045-97-2,145046-08-8
tert-Butyl (4E)-1--5-cyano-8-(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-3,3-dimethyl-1,2,3,10-dihydropyrrin-9-carboxylate

: 145045-98-3,145046-09-9
2-[5-[1-[5-Carboxy-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-1-cyano-meth-(E)-ylidene]-4,4-dimethyl-pyrrolidin-(2E)-ylidene]-malonic acid monobenzyl ester

Guidance literature:: With trifluoroacetic acid; at 0 ℃; for 0.166667h;
DOI:10.1039/P19920002175

Reference yield:

: 157646-08-7
t-butyl 5--3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrole-2-carboxylate

: 145045-98-3,145046-09-9
2-[5-[1-[5-Carboxy-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-1-cyano-meth-(E)-ylidene]-4,4-dimethyl-pyrrolidin-(2E)-ylidene]-malonic acid monobenzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / Lawesson's reagent / toluene / 0.83 h / Heating

2: 1) NaH / 1) THF, 10 min, r.t., 2) THF, 10 min

3: 65 percent / Ph₃P, DBU / toluene / 0.5 h / Heating

4: CF₃CO₂H / 0.17 h / 0 °C

With Lawessons reagent; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; trifluoroacetic acid; In toluene;
DOI:10.1039/P19920002175

Reference yield:

: 145045-95-0
tert-Butyl (E)-5-cyano-8-(2-methoxycarbonylethyl)-7-methoxycarbonylmethyl-3,3-dimethyl-1-thioxo-1,2,3,10-tetrahydrodipyrrin-2-carboxylate

: 145045-98-3,145046-09-9
2-[5-[1-[5-Carboxy-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-1H-pyrrol-2-yl]-1-cyano-meth-(E)-ylidene]-4,4-dimethyl-pyrrolidin-(2E)-ylidene]-malonic acid monobenzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NaH / 1) THF, 10 min, r.t., 2) THF, 10 min

2: 65 percent / Ph₃P, DBU / toluene / 0.5 h / Heating

3: CF₃CO₂H / 0.17 h / 0 °C

With sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; trifluoroacetic acid; In toluene;
DOI:10.1039/P19920002175